Die folgenden Gennamen und Gensymbole werden für Antigen APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 über verschiedene Spezies hinweg verwendet:

apurinic/apyrimidinic endonuclease 1 (Apex1), APEX nuclease (multifunctional DNA repair enzyme) 1 (Apex1), APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), APEX nuclease (multifunctional DNA repair enzyme) 1 (apex1), DNA-apurinic or apyrimidinic site lyase (apex1), DNA-(apurinic or apyrimidinic site) lyase (CNG03640), DNA-(apurinic or apyrimidinic site) lyase (CNH01280), DNA-(apurinic or apyrimidinic site) lyase (nth), DNA-(apurinic or apyrimidinic site) lyase (Spirs_4119), DNA-(apurinic or apyrimidinic site) lyase (Palpr_0103)

Zu den weiteren Synonymen zählen:

APE, Apex, HAP1, Ref-1, APEX1, APEN, BAP1, MGC139790, MGC113976, zgc:66204, wu:fc13d11, hm:zehn1532, apex1, MGC76280, MGC79645, MGC78928, APX, APE1, APEX, REF1

Auf Proteinebene tauchen folgende Bezeichner für Antigen APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 auf:

APEX nuclease 1 – OTTMUSP00000021336 – apurinic/apyrimidinic endonuclease 1 – AP lyase – AP endonuclease 1 – apurinic/apyrimidinic endonuclease – zap1 – APEX nuclease (multifunctional DNA repair enzyme) 1 – redox factor 1 – AP endonuclease class I – apurinic/apyrimidinic exonuclease – multifunctional DNA repair enzyme – DNA-(apurinic or apyrimidinic site) lyase – apurinic/apyrimidinic (abasic) endonuclease – deoxyribonuclease (apurinic or apyrimidinic)

APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 erfüllt eine Reihe von Funktionen:

DNA binding – DNA-(apurinic or apyrimidinic site) lyase activity – endonuclease activity – lyase activity – magnesium ion binding – metal ion binding – nuclease activity – oxidoreductase activity – protein binding – protein complex binding – transcription coactivator activity – transcription regulator activity – phosphoric diester hydrolase activity – 3'-5' exonuclease activity – endodeoxyribonuclease activity – phosphodiesterase I activity – ribonuclease H activity – transcription corepressor activity – uracil DNA N-glycosylase activity – oxidized pyrimidine base lesion DNA N-glycosylase activity

APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 spielt in den folgenden Prozessen eine Rolle:

DNA repair – cell redox homeostasis – response to DNA damage stimulus – regulation of DNA binding – heart contraction – heart looping – negative regulation of apoptosis – base-excision repair – transcription from RNA polymerase II promoter – base-excision repair, AP site formation

APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 ist wie folgt lokalisiert:

cytoplasm – intracellular – nucleus – centrosome – nucleoplasm – perinuclear region of cytoplasm – endoplasmic reticulum – ribosome – mitochondrion

Quelle: NCBI Entrez Gene, Gene Ontology