Die folgenden Gennamen und Gensymbole werden für Antigen ADAM Metallopeptidase Domain 10 über verschiedene Spezies hinweg verwendet:

ADAM metallopeptidase domain 10 (ADAM10), a disintegrin and metallopeptidase domain 10 (Adam10), ADAM metallopeptidase domain 10 (Adam10), a disintegrin and metalloprotease domain 10a (adam10a), ADAM metallopeptidase domain 10 (LOC100219653)

Zu den weiteren Synonymen zählen:

kuz, AD10, MADM, CD156c, HsT18717, kuzbanian, 1700031C13Rik, ADAM10, adam10, wu:fc03d12, ADAM-10, DKFZp459A157, LOC100219653, Adam10

Auf Proteinebene tauchen folgende Bezeichner für Antigen ADAM Metallopeptidase Domain 10 auf:

ADAM metallopeptidase domain 10 – kuzbanian – a disintegrin and metalloprotease domain 10 – a disintegrin and metalloproteinase domain 10 – a disintegrin and metalloprotease domain (ADAM) 10 – a disintegrin and metallopeptidase domain 10 – ADAM 10 – a disintegrin and metalloprotease domain 10a – disintegrin-metalloproteinase – ADAM10 metallopeptidase – disintegrin and metalloproteinase domain-containing protein 10-like

ADAM Metallopeptidase Domain 10 erfüllt eine Reihe von Funktionen:

SH3 domain binding – integrin binding – metal ion binding – metalloendopeptidase activity – peptidase activity – protein homodimerization activity – protein kinase binding – zinc ion binding – SH2 domain binding – endopeptidase activity – hydrolase activity – metallopeptidase activity – protein binding

ADAM Metallopeptidase Domain 10 spielt in den folgenden Prozessen eine Rolle:

Notch signaling pathway – PMA-inducible membrane protein ectodomain proteolysis – cell-cell signaling – constitutive protein ectodomain proteolysis – in utero embryonic development – integrin-mediated signaling pathway – monocyte activation – negative regulation of cell adhesion – positive regulation of T cell chemotaxis – positive regulation of cell growth – positive regulation of cell migration – positive regulation of cell proliferation – protein amino acid phosphorylation – proteolysis – response to tumor necrosis factor – Notch receptor processing – nucleocytoplasmic transport – membrane protein ectodomain proteolysis – regulation of osteoclast differentiation

ADAM Metallopeptidase Domain 10 ist wie folgt lokalisiert:

Golgi apparatus – Golgi-associated vesicle – cell surface – cytoplasm – integral to membrane – nucleus – plasma membrane – postsynaptic density – membrane – proteinaceous extracellular matrix – membrane fraction – trans-Golgi network – extracellular region

Quelle: NCBI Entrez Gene, Gene Ontology