Die folgenden Gennamen und Gensymbole werden für Antigen 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase über verschiedene Spezies hinweg verwendet:

3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR), 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), HMGCoA reductase (HMGCR), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hmgcr), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), novel protein similar to vertebrate 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) (LOC796384), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Mmah_0566), 3-hydroxy-3-methylglutaryl-coenzyme a reductase (Mfer_0012), 3-hydroxy-3-methylglutaryl-coenzyme a reductase (Ftrac_1626), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), 3-hydroxy-3-methylglutaryl-CoA reductase (hmgcr), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)

Zu den weiteren Synonymen zählen:

LDLCQ3, Red, HMG-CoAR, MGC103269, 3H3M, HMGR, hmgcr, MGC82101, HMGCR, MGC166255, hmg-coa-r, Hmgcr, GB18242, LOC796384, DKFZp459A201

Auf Proteinebene tauchen folgende Bezeichner für Antigen 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase auf:

3-hydroxy-3-methylglutaryl-Coenzyme A reductase – hydroxymethylglutaryl-CoA reductase – 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) – 3-hydroxy-3-methylglutaryl-CoA reductase – 3-hydroxy-3-methylglutaryl-coenzyme A reductase – HMG-CoA reductase – 3-hydroxy-3-methylglutaryl CoA reductase – 3-hydroxy-3-methylglutaryl-coenzyme a reductase – 3-hydroxy-3-methylglutaryl-coenzyme A reductase-like

3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase erfüllt eine Reihe von Funktionen:

NADP or NADPH binding – hydroxymethylglutaryl-CoA reductase (NADPH) activity – oxidoreductase activity – coenzyme binding – hydroxymethylglutaryl-CoA reductase activity – protein homodimerization activity

3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase spielt in den folgenden Prozessen eine Rolle:

cholesterol biosynthetic process – coenzyme A metabolic process – germ cell migration – gonad development – isoprenoid biosynthetic process – oxidation reduction – embryonic development – lipid biosynthetic process – negative regulation of MAP kinase activity – steroid biosynthetic process – sterol biosynthetic process – visual learning – farnesyl diphosphate biosynthetic process, mevalonate pathway

3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase ist wie folgt lokalisiert:

endoplasmic reticulum – endoplasmic reticulum membrane – integral to membrane – membrane – peroxisome – microsome

Quelle: NCBI Entrez Gene, Gene Ontology