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IKKi/IKKe Antikörper (pThr501)

Name: IKKi/IKKe Antikörper (pThr501)
SKU: ABIN116937
Availability: InStock

Der Kaninchen Polyklonal anti-IKKi/IKKe Antikörper (ABIN116937) detektiert spezifisch IKKi/IKKe in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Produktnummer ABIN116937

1.129,23 €

Zzgl. Versandkosten 20,00 € und MwSt

0.1 mg

Lieferung nach: Deutschland

Lieferung in 16 Werktagen

Kurzübersicht für IKKi/IKKe Antikörper (pThr501) (ABIN116937)

Target

Alle IKKi/IKKe (IKBKE) Antikörper anzeigen

IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Reaktivität

Human

Wirt

Kaninchen

Klonalität

Polyklonal

Konjugat

Dieser IKKi/IKKe Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), Enzyme Immunoassay (EIA)

Discover our top product IKBKE Primärantikörper

Bindungsspezifität
15

9

8

5

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
pThr501

Sequenz

R-S-R-L-R-pT-L-A-E-V-L

Spezifität

This phospho specific polyclonal antibody is specific for phosphorylated pThr501 IKKE. Reactivity with non-phosphorylated IKKE is minimal.

Aufreinigung

Immunoaffinity Chromatography against the phosphopeptide and cross adsorption against the non-phosphorylated form of the peptide followed by non-adsorption against a non-specific peptide backbone to further reduce non-specific reactivity.

Immunogen

IKKE phosphopeptide corresponding to a region of the human protein surrounding pThr501 conjugated to KLH. Genename: IKKe
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (AA 495-716) antibody
IKBKE Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (AA 686-716), (C-Term) antibody
IKBKE Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB3912 unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (C-Term) antibody
IKBKE Reaktivität: Human, Maus, Ratte WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (AA 541-640) antibody
IKBKE Reaktivität: Human ELISA, IHC (p) Wirt: Maus Monoclonal 1F7 unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) antibody
IKBKE Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (AA 544-680) antibody
IKBKE Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (AA 1-257) antibody
IKBKE Reaktivität: Human ELISA Wirt: Maus Monoclonal 6B4B5 unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) antibody
IKBKE Reaktivität: Human WB, FACS Wirt: Kaninchen Monoclonal 23GB2720 unconjugated Recombinant Antibody

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (AA 686-716) antibody
IKBKE Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (pSer172) antibody
IKBKE Reaktivität: Maus, Ratte WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

This phospho specific polyclonal antibody reacts with phosphorylated human IKKE atpT501 and shows minimal reactivity by Western blot with non-phosphorylated IKKE andminimal reactivity by ELISA against the non-phosphorylated form of the immunizingpeptide. Although not tested, this antibody is likely functional in Immunohistochemistryand Immunoprecipitation.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.15 mg/mL (by UV absorbance at 280 nm)

Buffer

0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 with 0.09 % Sodium Azide as preservative.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target

IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Andere Bezeichnung

IKBKE / IKKE

Hintergrund

Nuclear Factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during the activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cytoplasm of the cell, which inhibit NF-κB activity. IκB proteins are phosphorylated by an IκB kinase complex consisting of at least three proteins, IKKa, IKKb, and IKKg. Isolated from a cDNA library of LPS-stimulated mouse macrophage cells, a novel molecule in the IKK complex has been recently identified and designated IKKi and/or IKKe. IKKe is required for the activation of NF-κB by mitogens and T cell receptors but not by TNFa or IL-1. LPS increases the IKKe mRNA level in mouse macrophage cell lines. This protein has significant sequence homology with kinase domains of IKKa and IKKb. Overexpression of wild type IKKe in cells phosphorylates Ser32 and Ser36 of IκBa.Synonyms: I kappa-B kinase epsilon, IKK-E, IKK-I, IKK-epsilon, IKKI, Inducible I kappa-B kinase, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, KIAA0151

Gen-ID

9641

NCBI Accession

NP_001180250

UniProt

Q14164

Pathways

TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades