Ezrin (EZR) Antikörper

Antigen: Ezrin (EZR)

Synonyme: CVL, CVIL, VIL2, MGC1584, FLJ26216, DKFZp762H157, EZR, vil2, wu:fc05c03, wu:fj31d06, cvl, cvil, MGC97499

Klonalität: Monoklonal (3C12)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN99023

Produktbeschreibung

Weitere Bezeichnung: Ezrin

Immunogen: BALB/C mice were immunized with a recombinant fragment of human ezrin corresponding to amino acid 362-585.

Format: Purified

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 3C12

Spezifität: This antibody with a protein of 70 kD. Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF- stimulated cells. Ezrin is a cytoplasmic protein enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas. This antibody cross reacts with monkey, cow, kangaroo, rat, mouse and hamster.

Anwendungen

Applikationshinweise: Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Positive Control: Lung. Cellular localization: Cell membrane Other Applications: Immunoprecipitation, Western blotting (1:100-750).

Konzentration: 100ug/ml approximately

Buffer: This antibody is supplied as purified ascites containing sodium azide as preservative.

Lagerung: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Beschränkungen: Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.

Bilder

Formalin fixed paraffin embedded human lung stained with Ezrin antibody

Publikationen

Publikationen: Boehling, Turunen, Jaeaeskelaeinen et al.: "Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors." in: The American journal of pathology, Vol. 148, Issue 2, pp. 367-73, 1996 (PubMed).

Helander, Carpuen, Turunen et al.: "ICAM-2 redistributed by ezrin as a target for killer cells." in: Nature, Vol. 382, Issue 6588, pp. 265-8, 1996 (PubMed).