CIITA Antikörper (AA 1)

Produktnummer ABIN97339

Produktdetails anti-CIITA Antikörper

Target: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Bindungsspezifität: AA 1

Reaktivität: Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CIITA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Concentration Definition: by Refractometry

Immunogen: The immunogen used for this study was a bacterially produced recombinant FLAG-CIITA corresponding to through 333 of the human protein.
Immunogentype:Recombinant

Anwendungsinformationen

Applikationshinweise: For immunoblotting a 1:500 dilution is recommended. Researchers should determine optimal titers for other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 90 mg/mL

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-CIITA Antikörper (ABIN97339)

Majumder, Lee, Rahmberg, Kumar, Mi, Scharer, Boss: "A super enhancer controls expression and chromatin architecture within the MHC class II locus." in: The Journal of experimental medicine, Vol. 217, Issue 2, (2020) (PubMed).

Scharer, Choi, Barwick, Majumder, Lohsen, Boss: "Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment." in: Nucleic acids research, Vol. 43, Issue 6, pp. 3128-42, (2015) (PubMed).

Koues, Dudley, Mehta, Greer: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." in: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, (2009) (PubMed).

Details zu CIITA

Target: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Andere Bezeichnung: CIITA (CIITA Produkte)

Synonyme: CIITA antikoerper, C2ta antikoerper, EG669998 antikoerper, Gm9475 antikoerper, C2TA antikoerper, CIITAIV antikoerper, MHC2TA antikoerper, NLRA antikoerper, Mhc2ta antikoerper, class II, major histocompatibility complex, transactivator antikoerper, class II major histocompatibility complex transactivator antikoerper, MHC class II transactivator antikoerper, class II transactivator antikoerper, CIITA antikoerper, LOC710761 antikoerper, ciita antikoerper, LOC100443575 antikoerper, Ciita antikoerper, LOC100736732 antikoerper

Hintergrund: Anti-CIITA antibody detects CIITA. The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.
Synonyms: MHC class II transactivator CIITA MHC2TA

Gen-ID: 4261

UniProt: P33076

Pathways: Cancer Immune Checkpoints