Osteoprotegerin Antikörper

Produktnummer ABIN969440

Produktdetails anti-Osteoprotegerin Antikörper

Target: Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Osteoprotegerin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human TNFRSF11B expressed in E. coli.

Klon: 5A11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-Osteoprotegerin Antikörper (ABIN969440)

Golledge, Biros, Clancy, Cooper, Palmer, Norman: "A single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated with diastolic blood pressure in older men." in: American journal of hypertension, Vol. 22, Issue 11, pp. 1167-70, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Details zu Osteoprotegerin

Target: Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))

Andere Bezeichnung: TNFRSF11B (TNFRSF11B Produkte)

Synonyme: CD254 antikoerper, ODF antikoerper, OPGL antikoerper, OPTB2 antikoerper, RANKL antikoerper, TRANCE antikoerper, hRANKL2 antikoerper, sOdf antikoerper, OCIF antikoerper, OPG antikoerper, TR1 antikoerper, Opg antikoerper, ocif antikoerper, opg antikoerper, tr1 antikoerper, TNF superfamily member 11 antikoerper, TNF receptor superfamily member 11b antikoerper, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) antikoerper, TNF receptor superfamily member 11B antikoerper, tumor necrosis factor receptor superfamily member 11b S homeolog antikoerper, tumor necrosis factor receptor superfamily, member 11b antikoerper, TNFSF11 antikoerper, TNFRSF11B antikoerper, Tnfrsf11b antikoerper, tnfrsf11b.S antikoerper

Substanzklasse: Chemical

Hintergrund:

Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Aliases: OPG, TR1, OCIF, MGC29565, TNFRSF11B

Molekulargewicht: 60 kDa

Gen-ID: 4982

HGNC: 4982