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SMAD4 Antikörper

Name: SMAD4 Antikörper
Brand: antibodies-online
SKU: ABIN969403
Price: 562.94 EUR
Availability: InStock

SMAD4 Reaktivität: Human WB, ELISA, IHC, ICC, FACS Wirt: Maus Monoclonal 4G1C6 unconjugated

Western blot analysis using SMAD4 mouse mAb against A431 (1), SK-N-SH (2), K562 (3), HepG2 (4) and HUVE12 (5) cell lysate.

Flow cytometric analysis of K562 cells using SMAD4 mouse mAb (green) and negative control (purple).

FACS

Immunofluorescence analysis of NIH/3T3 cells using SMAD4 mouse mAb (green).

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using SMAD4 mouse mAb with DAB staining.

IHC

4 Abbildungen

(2 Referenzen)

Produktnummer ABIN969403

Datenblatt (PDF)

Target Alle SMAD4 Antikörper anzeigen

SMAD4 (SMAD Family Member 4 (SMAD4))
Reaktivität
99

42

37

4

3

3

2

2

2

2

2

2

1

1
Human
Wirt
89

10

1
Maus
Passende Sekundärantikörper
Klonalität
75

25
Monoklonal
Konjugat
56

9

8

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1
Dieser SMAD4 Antikörper ist unkonjugiert
Applikation
65

45

34

30

22

13

9

7

6

3

2

2

2

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Aufreinigung

purified

Immunogen

Purified recombinant fragment of human SMAD4 expressed in E. coli. ,

Klon

4G1C6

Isotyp

IgG1

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SMAD4 Reaktivität: Human WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

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SMAD4 Reaktivität: Human WB, IF, IHC (p), FACS Wirt: Kaninchen Polyclonal RB20720 unconjugated

anti-SMAD Family Member 4 (SMAD4) (AA 118-240) antibody
SMAD4 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

anti-SMAD Family Member 4 (SMAD4) (pThr277) antibody
SMAD4 Reaktivität: Human ELISA, IHC, IF, DB Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

4°C, -20°C for long term storage
Yao, Yin, Lian, Tian, Liu, Li, Sun: "MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 3, pp. 540-51, (2010) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).
Target

SMAD4 (SMAD Family Member 4 (SMAD4))

Andere Bezeichnung

SMAD4 (SMAD4 Produkte)

Synonyme

smad4 antikoerper, DPC4 antikoerper, JIP antikoerper, MADH4 antikoerper, MYHRS antikoerper, AW743858 antikoerper, D18Wsu70e antikoerper, Madh4 antikoerper, XSmad4alpha antikoerper, Xsmad4 antikoerper, dpc4 antikoerper, jip antikoerper, madh4 antikoerper, xsmad4a antikoerper, SMAD family member 4 antikoerper, Smad4 protein antikoerper, SMAD family member 4, gene 1 L homeolog antikoerper, SMAD4 antikoerper, smad4 antikoerper, Smad4 antikoerper, smad4.1.L antikoerper

Hintergrund

Description: Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily, SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor.Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Aliases: JIP, DPC4, MADH4, SMAD4

Molekulargewicht

65 kDa

Gen-ID

4089

HGNC

4089

Pathways

Zellzyklus, Chromatin Binding, Autophagie