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RAG2 Antikörper (AA 350-527)

RAG2 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 4D5 unconjugated
Produktnummer ABIN969379
  • Target Alle RAG2 Antikörper anzeigen
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Bindungsspezifität
    • 15
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 350-527
    Reaktivität
    • 45
    • 14
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 40
    • 6
    Maus
    Klonalität
    • 42
    • 4
    Monoklonal
    Konjugat
    • 22
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RAG2 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 13
    • 13
    • 11
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human RAG2(350-527aa) expressed in E. coli.
    Klon
    4D5
    Isotyp
    IgG1
    Top Product
    Discover our top product RAG2 Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Nagawa, Hirose, Nishizumi, Nishihara, Sakano: "Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38360-8, (2004) (PubMed).

  • Target
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Andere Bezeichnung
    RAG2 (RAG2 Produkte)
    Synonyme
    RAG-2 antikoerper, Rag-2 antikoerper, rag-2 antikoerper, zgc:136743 antikoerper, recombination activating 2 antikoerper, recombination activating gene 2 antikoerper, recombination activating gene 2 S homeolog antikoerper, RAG2 antikoerper, Rag2 antikoerper, rag2 antikoerper, rag2.S antikoerper
    Hintergrund

    Description: This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

    Aliases: RAG-2, RAG2

    Molekulargewicht
    59 kDa
    Gen-ID
    5897
    HGNC
    5897
    Pathways
    Chromatin Binding, Production of Molecular Mediator of Immune Response
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