PDPK1 Antikörper (3-phosphoinositide Dependent Protein Kinase-1)

Details for Product anti-PDPK1 Antibody No. ABIN969347, Anbieter: Anmelden zum Anzeigen
Antigen
  • pdpk1
  • MGC82080
  • PDK1
  • PDPK2
  • PRO0461
  • Pdk1
  • si:zfos-979f1.3
  • 1210
  • BG02759
  • CG1201
  • CG1210
  • DSTPK61
  • Dmel\\CG1210
  • Dstpk61
  • PDK
  • PDK-1
  • PDK1/Pk61C
  • PK61C
  • Pk61C
  • Pk61C/PDK1
  • dPDK-1
  • dPDK1
  • dSTPK61
  • pk61c
  • 3'-phosphoinositide-dependent protein kinase 1
  • 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
  • ATPDK1
  • AtPDK1
  • T32M21.110
  • T32M21_110
  • 3-phosphoinositide dependent protein kinase 1
  • 3-phosphoinositide dependent protein kinase 1 L homeolog
  • 3-phosphoinositide dependent protein kinase-1
  • 3-phosphoinositide-dependent protein kinase 1
  • pyruvate dehydrogenase kinase, isozyme 1
  • pyruvate dehydrogenase kinase 1
  • Phosphoinositide-dependent kinase 1
  • 3'-phosphoinositide-dependent protein kinase 1
  • PDPK1
  • pdpk1.L
  • pdpk1
  • Pdpk1
  • LOC100380750
  • pdk1
  • PDK1
  • Pdk1
  • pdk-1
Reaktivität
Human, Affe, Ratte (Rattus)
462
219
218
18
13
12
11
11
6
5
4
3
2
1
1
1
1
1
1
1
Wirt
Maus
382
72
16
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser PDPK1 Antikörper ist unkonjugiert
19
17
16
11
11
7
7
7
7
7
7
7
7
7
7
6
5
5
5
4
3
3
3
2
2
1
1
1
1
1
Applikation
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
311
157
99
91
67
64
39
30
22
10
7
5
3
2
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Purified recombinant fragment of human PDK1 expressed in E. Coli.
Klon 4A11
Isotyp IgG1
Reinigung Ascites
Andere Bezeichnung PDK1 (PDPK1 Antibody Abstract)
Hintergrund Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. (provided by RefSeq). Tissue specificity: Expressed predominantly in the heart.
Molekulargewicht 44 kDa
Gen-ID 5163
HGNC 5163
Forschungsgebiet Signaling, Cytoskeleton, Microfilaments, Kinases/Phosphatases
Pathways PI3K-Akt Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
Applikationshinweise ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) antibody (ABIN969347) Figure 1: Flow cytometric analysis of Lovo cells using PDK1 mouse mAb (green) and neg...
Immunocytochemistry (ICC) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) antibody (ABIN969347) Figure 2: Immunofluorescence analysis of HELA cells using PDK1 mouse mAb (green) . Bl...
Immunohistochemistry (IHC) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) antibody (ABIN969347) Figure 3: Immunohistochemical analysis of paraffin-embedded breast cancer tissues (le...
Western Blotting (WB) image for anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) antibody (ABIN969347) Figure 4: Western blot analysis using PDK1 mouse mAb against NIH/3T3 (1), Hela (2), J...
Produkt verwendet in: Weisberg, Banerji, Wright, Barrett, Ray, Moreno, Catley, Jiang, Hall-Meyers, Sauveur-Michel, Stone, Galinsky, Fox, Kung, Griffin: "Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells." in: Blood, Vol. 111, Issue 7, pp. 3723-34, 2008 (PubMed).

Pinner, Sahai: "PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE." in: Nature cell biology, Vol. 10, Issue 2, pp. 127-37, 2008 (PubMed).

Seong, Jung, Kim, Ha: "3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins." in: The Journal of biological chemistry, Vol. 282, Issue 16, pp. 12272-89, 2007 (PubMed).

Haben Sie etwas anderes gesucht?