NAC1 Antikörper

Produktnummer ABIN969307

Produktdetails anti-NAC1 Antikörper

Target: NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NAC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human NACC1 expressed in E. coli.

Klon: 6H2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Details zu NAC1

Target: NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))

Andere Bezeichnung: NACC1 (NACC1 Produkte)

Synonyme: BEND8 antikoerper, BTBD14B antikoerper, BTBD30 antikoerper, NAC-1 antikoerper, NAC1 antikoerper, NACC1 antikoerper, 2010001H03Rik antikoerper, 4930511N13Rik antikoerper, Btbd14b antikoerper, Nac1 antikoerper, Nac-1 antikoerper, nucleus accumbens associated 1 antikoerper, nucleus accumbens associated 1, BEN and BTB (POZ) domain containing antikoerper, NACC1 antikoerper, Nacc1 antikoerper

Hintergrund:

Description: NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer .

Aliases: NAC1, BEND8, NAC-1, BTBD14B, FLJ37383, NACC1

Molekulargewicht: 58 kDa

Gen-ID: 112939

HGNC: 112939