Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antikörper

Details zu Produkt Nr. ABIN969178, Anbieter: Anmelden zum Anzeigen
Antigen
  • Adrbk-1
  • Bark-1
  • GRK2
  • betaARK1
  • BARK1
  • BETA-ARK1
  • GRK-2
  • Grk2
  • beta-adrenergic receptor kinase 1
  • G protein-coupled receptor kinase 2
  • Tsp_00497
  • grk2
  • Grk2
  • GRK2
Reaktivität
Human, Maus, Ratte (Rattus), Affe
135
71
70
17
12
12
9
5
4
3
3
1
1
1
1
Wirt
Maus
93
25
16
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
4
4
4
1
1
1
Applikation
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
117
72
52
25
18
10
4
3
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Purified recombinant fragment of human GRK2 expressed in E. Coli.
Klon 3F8
Isotyp IgG1
Reinigung Ascites
Andere Bezeichnung GRK2 (ADRBK1 Antibody Abstract)
Hintergrund The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes
Molekulargewicht 80 kDa
Gen-ID 156
HGNC 156
Forschungsgebiet Signaling
Pathways EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
Applikationshinweise ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
ELISA image for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody (ABIN969178) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Immunocytochemistry (ICC) image for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody (ABIN969178) Figure 2: Immunofluorescence analysis of NIH/3T3 cells using GRK2 mouse mAb (green) ....
Immunohistochemistry (IHC) image for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody (ABIN969178) Figure 3: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissue...
Western Blotting (WB) image for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody (ABIN969178) Figure 4: Western blot analysis using GRK2 mouse mAb against Hela (1), Jurkat (2), MO...
Produkt verwendet in: Sterne-Marr, Leahey, Bresee, Dickson, Ho, Ragusa, Donnelly, Amie, Krywy, Brookins-Danz, Orakwue, Carr, Yoshino-Koh, Li, Tesmer: "GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail." in: Biochemistry, Vol. 48, Issue 20, pp. 4285-93, 2009 (PubMed).

Chen, Long, Wu, Jiang, Ma: "EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2973-83, 2008 (PubMed).

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