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KRT17 Antikörper

KRT17 Reaktivität: Human WB, IHC, ELISA Wirt: Maus Monoclonal 3B12 unconjugated
Produktnummer ABIN969058
  • Target Alle KRT17 Antikörper anzeigen
    KRT17 (Keratin 17 (KRT17))
    Reaktivität
    • 123
    • 47
    • 29
    • 18
    • 13
    • 11
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 100
    • 34
    Maus
    Klonalität
    • 87
    • 47
    Monoklonal
    Konjugat
    • 56
    • 16
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KRT17 Antikörper ist unkonjugiert
    Applikation
    • 102
    • 43
    • 37
    • 31
    • 27
    • 26
    • 22
    • 20
    • 18
    • 15
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of CK17 expressed in E. coli.
    Klon
    3B12
    Isotyp
    IgG2b
    Top Product
    Discover our top product KRT17 Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • van de Rijn, Perou, Tibshirani, Haas, Kallioniemi, Kononen, Torhorst, Sauter, Zuber, Köchli, Mross, Dieterich, Seitz, Ross, Botstein, Brown: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." in: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, (2002) (PubMed).

  • Target
    KRT17 (Keratin 17 (KRT17))
    Andere Bezeichnung
    CK17 (KRT17 Produkte)
    Synonyme
    K17 antikoerper, Krt1-17 antikoerper, PC antikoerper, PC2 antikoerper, PCHC1 antikoerper, Ka17 antikoerper, KRT17 antikoerper, krt16 antikoerper, si:dkeyp-113d7.7 antikoerper, KRT14 antikoerper, keratin 17 antikoerper, keratin 17 L homeolog antikoerper, keratin 17, type I antikoerper, keratin, type I cytoskeletal 17 antikoerper, Krt17 antikoerper, KRT17 antikoerper, krt17 antikoerper, krt17.L antikoerper, LOC100737113 antikoerper, LOC102177275 antikoerper
    Hintergrund

    Description: CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

    Aliases: PC, K17, PC2, PCHC1, KRT17

    Molekulargewicht
    49 kDa
    Gen-ID
    3872
    HGNC
    3872
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