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B-Cell Linker Antikörper

BLNK Reaktivität: Human, Maus WB, ELISA, IHC, FACS, ICC Wirt: Maus Monoclonal 5G9 unconjugated
Produktnummer ABIN968984
  • Target Alle B-Cell Linker (BLNK) Antikörper anzeigen
    B-Cell Linker (BLNK)
    Reaktivität
    • 109
    • 74
    • 38
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 113
    • 14
    • 1
    Maus
    Klonalität
    • 108
    • 20
    Monoklonal
    Konjugat
    • 53
    • 8
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    Dieser B-Cell Linker Antikörper ist unkonjugiert
    Applikation
    • 110
    • 52
    • 35
    • 26
    • 25
    • 19
    • 17
    • 8
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human BLNK expressed in E. coli.
    Klon
    5G9
    Isotyp
    IgG1
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).

    Kamino, Futamura, Nakamura, Kitamura, Kabu, Arakawa: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." in: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).

  • Target
    B-Cell Linker (BLNK)
    Andere Bezeichnung
    BLNK (BLNK Produkte)
    Synonyme
    BLNK antikoerper, blnk antikoerper, MGC147045 antikoerper, BASH antikoerper, Bca antikoerper, Ly-57 antikoerper, Ly57 antikoerper, Lyw-57 antikoerper, SLP-65 antikoerper, AGM4 antikoerper, BLNK-S antikoerper, LY57 antikoerper, SLP65 antikoerper, bca antikoerper, B-cell linker antikoerper, B cell linker antikoerper, BLNK antikoerper, blnk antikoerper, Blnk antikoerper
    Hintergrund

    Description: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

    Aliases: AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051

    Molekulargewicht
    68 kDa
    Gen-ID
    29760
    HGNC
    29760
    Pathways
    BCR Signaling
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