ATF2 Antikörper (Activating Transcription Factor 2)

Details for Product anti-ATF2 Antibody No. ABIN968968, Anbieter: Anmelden zum Anzeigen
Antigen
  • CRE-BP1
  • CREB2
  • HB16
  • TREB7
  • CG12850
  • CG3749
  • dATF-2
  • DmelCG30420
  • CG30420
  • CHN1
  • Atf-2
  • CRE-BP
  • Creb2
  • D130078H02Rik
  • D18875
  • Tg(Gzma-Klra1)7Wum
  • mXBP
  • atf2-A
  • atf2l
  • activating transcription factor 2
  • Activating transcription factor-2
  • activating transcription factor 2 S homeolog
  • ATF2
  • Atf-2
  • Atf2
  • atf2.S
  • atf2
Reaktivität
Human, Maus
659
391
352
30
21
14
14
12
10
8
5
5
2
2
2
2
1
1
Wirt
Maus
582
56
19
4
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser ATF2 Antikörper ist unkonjugiert
16
15
15
10
10
9
9
9
9
9
9
9
9
9
7
6
6
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
456
256
164
132
118
114
81
23
21
11
8
6
6
3
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Purified recombinant fragment of human ATF2 expressed in E. Coli.
Klon 4F12
Isotyp IgG1
Reinigung Ascites
Andere Bezeichnung ATF2 (ATF2 Antibody Abstract)
Hintergrund This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro, thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.Tissue specificity: Abundant expression seen in the brain.
Molekulargewicht 55 kDa
Gen-ID 1386
HGNC 1386
Forschungsgebiet Immunology, Innate Immunity, Transcription Factors
Pathways MAPK Signalweg, RTK Signalweg, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades
Applikationshinweise ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
ELISA image for anti-Activating Transcription Factor 2 (ATF2) antibody (ABIN968968) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Immunohistochemistry (IHC) image for anti-Activating Transcription Factor 2 (ATF2) antibody (ABIN968968) Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left) and br...
Western Blotting (WB) image for anti-Activating Transcription Factor 2 (ATF2) antibody (ABIN968968) Figure 3: Western blot analysis using ATF2 mouse mAb against NIH/3T3 cell lysate.
Produkt verwendet in: Chen, Takeuchi, Moroi, Hayashida, Kido, Chen, Tomoeda, Uenotsuchi, Tu, Furue, Urabe: "Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous squamous cell carcinoma, Bowen's disease and basal cell carcinoma." in: Journal of dermatological science, Vol. 51, Issue 3, pp. 210-5, 2008 (PubMed).

Bhoumik, Singha, OConnell, Ronai: "Regulation of TIP60 by ATF2 modulates ATM activation." in: The Journal of biological chemistry, Vol. 283, Issue 25, pp. 17605-14, 2008 (PubMed).

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