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CD103 Antikörper (PE)

ITGAE Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal Ber-ACT8 PE
Produktnummer ABIN968934
  • Target Alle CD103 (ITGAE) Antikörper anzeigen
    CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))
    Reaktivität
    • 74
    • 38
    • 8
    • 5
    • 4
    • 3
    Human, Non-Human Primate
    Wirt
    • 41
    • 40
    • 16
    • 15
    • 4
    Maus
    Klonalität
    • 84
    • 32
    Monoklonal
    Konjugat
    • 44
    • 13
    • 12
    • 8
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser CD103 Antikörper ist konjugiert mit PE
    Applikation
    • 58
    • 38
    • 26
    • 24
    • 22
    • 15
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody Ber-ACT8 recognizes an extracellular epitope of CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    HTLV-1 induced human T cell line MAPS16
    Klon
    Ber-ACT8
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product ITGAE Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Rekonstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Zhang, Bertucci, Ramsey-Goldman, Burt, Datta et al.: "Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 10, pp. 6346-58, (2009) (PubMed).

    Kost, Holden, Mann: "Marginal zone B-cell lymphoma: a retrospective immunophenotypic analysis." in: Cytometry. Part B, Clinical cytometry, Vol. 74, Issue 5, pp. 282-6, (2008) (PubMed).

    Cardoso, Garlet, Moreira, Júnior, Rossi, Silva: "Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis." in: Journal of leukocyte biology, Vol. 84, Issue 1, pp. 311-8, (2008) (PubMed).

    Jaensson, Uronen-Hansson, Pabst, Eksteen, Tian, Coombes, Berg, Davidsson, Powrie, Johansson-Lindbom, Agace: "Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans." in: The Journal of experimental medicine, Vol. 205, Issue 9, pp. 2139-49, (2008) (PubMed).

    León, Roy: "Isolation of human small bowel intraepithelial lymphocytes by annexin V-coated magnetic beads." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 84, Issue 6, pp. 804-9, (2004) (PubMed).

    Sigmundsdottir, Johnston, Gudjonsson, Bjarnason, Valdimarsson: "Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin." in: Experimental dermatology, Vol. 13, Issue 7, pp. 426-34, (2004) (PubMed).

    Poles, Barsoum, Yu, Yu, Sun, Daly, He, Mehandru, Talal, Markowitz, Hurley, Ho, Zhang: "Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy." in: Journal of virology, Vol. 77, Issue 19, pp. 10456-67, (2003) (PubMed).

    Brandes, Willimann, Lang, Nam, Jin, Brenner, Morita, Moser: "Flexible migration program regulates gamma delta T-cell involvement in humoral immunity." in: Blood, Vol. 102, Issue 10, pp. 3693-701, (2003) (PubMed).

    French, Cresswell, Wong, Seymour, Charnley, Kirby: "T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy?" in: British journal of cancer, Vol. 87, Issue 9, pp. 1034-41, (2002) (PubMed).

  • Target
    CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))
    Andere Bezeichnung
    CD103 (ITGAE Produkte)
    Synonyme
    A530055J10 antikoerper, CD103 antikoerper, aM290 antikoerper, alpha-E1 antikoerper, alpha-M290 antikoerper, HUMINAE antikoerper, integrin alpha E, epithelial-associated antikoerper, integrin subunit alpha E antikoerper, Itgae antikoerper, ITGAE antikoerper
    Hintergrund
    Integrin subunit alpha E,CD103 / integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.,Integrin alpha E, ITGAE
    Gen-ID
    3682
    UniProt
    P38570
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