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LIMS1 Antikörper (AA 120-220)

LIMS1 Reaktivität: Human, Maus, Ratte, Hund, Huhn WB, IF Wirt: Maus Monoclonal 49-PINCH unconjugated
Produktnummer ABIN968921
  • Target Alle LIMS1 Antikörper anzeigen
    LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
    Bindungsspezifität
    • 15
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 120-220
    Reaktivität
    • 59
    • 24
    • 16
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte, Hund, Huhn
    Wirt
    • 49
    • 10
    Maus
    Klonalität
    • 49
    • 10
    Monoklonal
    Konjugat
    • 20
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LIMS1 Antikörper ist unkonjugiert
    Applikation
    • 19
    • 13
    • 13
    • 13
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte (Rattus), Maus
    Keine Kreuzreaktivität
    Hund, Huhn
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human PINCH aa. 120-220
    Klon
    49-PINCH
    Isotyp
    IgG2a
    Top Product
    Discover our top product LIMS1 Primärantikörper
  • Kommentare

    Related Products: ABIN968586, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Campana, Myers, Rearden: "Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury." in: Glia, Vol. 41, Issue 3, pp. 213-23, (2003) (PubMed).

    Tu, Li, Goicoechea, Wu: "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells." in: Molecular and cellular biology, Vol. 19, Issue 3, pp. 2425-34, (1999) (PubMed).

    Tu, Li, Wu: "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways." in: Molecular biology of the cell, Vol. 9, Issue 12, pp. 3367-82, (1999) (PubMed).

  • Target
    LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
    Andere Bezeichnung
    PINCH (LIMS1 Produkte)
    Synonyme
    PINCH antikoerper, PINCH-1 antikoerper, PINCH1 antikoerper, Pinch1 antikoerper, RGD1560732 antikoerper, LIMS3 antikoerper, LIMS3L antikoerper, 2310016J22Rik antikoerper, 4921524A02Rik antikoerper, AI507642 antikoerper, AU021743 antikoerper, AW551584 antikoerper, C430041B13Rik antikoerper, Lims1l antikoerper, LIM zinc finger domain containing 1 antikoerper, LIM and senescent cell antigen-like domains 1 antikoerper, LIMS1 antikoerper, Lims1 antikoerper
    Hintergrund
    Integrins are transmembrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are heterodimers composed of alpha and beta subunits, which interact with extracellular matrix and cytoskeletal proteins. Signal transduction through intergin receptors may be regulated by integrin-linked kinase (ILK). ILK is a widely expressed Ser/Thr protein kinase that contains four ankyrin-like repeats in the N-terminal region, a phoshoinositide lipid-binding motif at amino acids 180-212, and an integrin binding site at amino acids 293-451. The ankyrin repeats interact with a LIM domain-only protein called PINCH that also binds the adaptor protein, Nck-2. This interaction implicates ILK in growth factor receptor pathways. The PINCH adaptor protein also contains a leucine-rich nuclear export signal and a nuclear localization signal. These two motifs implicate PINCH in nuclear functions, and in Schwann cells PINCH has been found in the nucleus, as well as, cytoplasm and perinuclear regions. Thus, PINCH is an adaptor protein that functions in both integrin signaling and nuclear functions.
    Molekulargewicht
    37 kDa
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