Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) Antikörper

Details zu Produkt Nr. ABIN968864, Anbieter: Anmelden zum Anzeigen
Antigen
  • CAS
  • CTNND
  • P120CAS
  • P120CTN
  • p120
  • p120(CAS)
  • p120(CTN)
  • Catns
  • cas
  • Xp120
  • ctnnd
  • p120cas
  • p120ctn
  • p120(ctn)
  • Xp120(ctn)
  • p120-catenin
  • CTNND1
  • AA409437
  • AU019353
  • Ctnnd
  • P120
  • mKIAA0384
  • catenin delta 1
  • catenin (cadherin-associated protein), delta 1
  • catenin (cadherin associated protein), delta 1
  • catenin delta 1 L homeolog
  • CTNND1
  • Ctnnd1
  • ctnnd1
  • ctnnd1.L
Epitop
pTyr228
25
19
18
17
15
9
7
6
5
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
235
122
120
19
15
5
5
5
5
4
4
1
Wirt
Maus
161
77
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
11
10
7
7
6
6
5
5
5
5
5
5
5
5
5
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
118
67
53
50
41
35
33
30
23
11
5
3
2
2
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Mouse p120 Catenin (pY228)
Klon 21a-p120 Catenin
Isotyp IgG1
Kreuzreaktivität Human, Ratte (Rattus)
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Andere Bezeichnung p120 Catenin (CTNND1 Antibody Abstract)
Hintergrund The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas)was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. This similarity is evidenced by its characteristic Arm domain that is composed of 42-amino acid motif repeats. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
Molekulargewicht 120 kDa
Pathways EGFR Signaling Pathway, Neurotrophin Signalübertragung, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
Kommentare

Related Products: ABIN967389, ABIN968536

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20° C.
Bilder des Herstellers
 image for anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) antibody (ABIN968864) Human Endothelial cells were treated with#1 mM pervanadate for 15 min at 37°C. The to...
Immunofluorescence (IF) image for anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) antibody (ABIN968864) Eahy cells were serum starved and treated with pervanadate (1mM) for 20 min., then fi...
Western Blotting (WB) image for anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) antibody (ABIN968864) anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) antibody (Image 3)
Produkt verwendet in: Mariner, Anastasiadis, Keilhack, Böhmer, Wang, Reynolds: "Identification of Src phosphorylation sites in the catenin p120ctn." in: The Journal of biological chemistry, Vol. 276, Issue 30, pp. 28006-13, 2001 (PubMed).

Reynolds, Daniel, McCrea, Wheelock, Wu, Zhang: "Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes." in: Molecular and cellular biology, Vol. 14, Issue 12, pp. 8333-42, 1994 (PubMed).

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