HERC2 Antikörper (AA 1781-1974)

Produktnummer ABIN968838

Produktdetails anti-HERC2 Antikörper

Target: HERC2 (Hect Domain and RLD 2 (HERC2))

Bindungsspezifität: AA 1781-1974

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HERC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse HERC2 aa. 1781-1974

Klon: 17-HERC2

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-HERC2 Antikörper (ABIN968838)

Ji, Rebert, Joslin, Higgins, Schultz, Nicholls: "Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human." in: Genome research, Vol. 10, Issue 3, pp. 319-29, (2000) (PubMed).

Lehman, Nakatsu, Ching, Bronson, Oakey, Keiper-Hrynko, Finger, Durham-Pierre, Horton, Newton, Lyon, Brilliant: "A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 16, pp. 9436-41, (1998) (PubMed).

Details zu HERC2

Target: HERC2 (Hect Domain and RLD 2 (HERC2))

Andere Bezeichnung: HERC2 (HERC2 Produkte)

Synonyme: CG11734 antikoerper, Dmel\\CG11734 antikoerper, D15F32S1h antikoerper, D7H15F32S1 antikoerper, D7H15F37S1 antikoerper, jdf2 antikoerper, mKIAA0393 antikoerper, rjs antikoerper, D15F37S1 antikoerper, SHEP1 antikoerper, p528 antikoerper, HECT and RLD domain containing protein 2 antikoerper, HECT and RLD domain containing E3 ubiquitin protein ligase 2 antikoerper, HERC2 antikoerper, Herc2 antikoerper

Hintergrund: Prader-Willi and Angelman syndromes are genetic disorders that result from recombination between chromsome-specific low-copy repeats (duplicons). ERC2(rjs) is the transcript found in the duplicon for these disorders, and recessive mutation of HERC2 leads to a developmental syndrome in mice, referred to as runty jerky sterile (rjs) and juvenile development and fertility 2 (jdf2). HERC2 is homologous to the HERC1 and HERC3 HECT-domain containing proteins. The sequence of HERC2 includes three RCC1-like domains (RLD), a C-terminal ECT domain, and a ZZ-type zinc finger. The RCC1 repeats are similar to those found in cytochrome b5 and the HECT domain is found in E6-AP ubiquitin ligase. HERC2 may function as both a guanine nucleotide exchange factor and E3 biquitin ligase based on its conserved motifs and observation from mouse mutation studies. HERC2 mRNA is expressed highest in brain and testes, but is also found in heart, lung, liver, skeletal muscle, and kidney. Thus, HERC2 may function in protein trafficking and degradation pathways in various tissues.

Molekulargewicht: 527 kDa