ARPC3 Antikörper (AA 10-118)

Produktnummer ABIN968781

Produktdetails anti-ARPC3 Antikörper

Target: ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3))

Bindungsspezifität: AA 10-118

Reaktivität: Human, Maus, Ratte, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ARPC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Maus, Ratte (Rattus), Huhn, Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human p21-Arc aa. 10-118

Klon: 26-p21

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-ARPC3 Antikörper (ABIN968781)

Zhao, Yang, Qian, Zhu: "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub." in: Biochemical and biophysical research communications, Vol. 280, Issue 2, pp. 513-7, (2001) (PubMed).

Welch, DePace, Verma, Iwamatsu, Mitchison: "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly." in: The Journal of cell biology, Vol. 138, Issue 2, pp. 375-84, (1997) (PubMed).

Details zu ARPC3

Target: ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3))

Andere Bezeichnung: p21-Arc (ARPC3 Produkte)

Synonyme: ARC21 antikoerper, p21-Arc antikoerper, 1110006A04Rik antikoerper, 21kDa antikoerper, AA408672 antikoerper, AI788639 antikoerper, p21-Ar antikoerper, p21Arc antikoerper, arc21 antikoerper, p21-arc antikoerper, zgc:86828 antikoerper, actin related protein 2/3 complex subunit 3 antikoerper, actin related protein 2/3 complex, subunit 3 antikoerper, actin related protein 2/3 complex subunit 3 L homeolog antikoerper, actin related protein 2/3 complex, subunit 3, 21kDa antikoerper, actin related protein 2/3 complex subunit 3 pseudogene antikoerper, actin-related protein 2/3 complex subunit 3 antikoerper, actin-related protein 2/3 complex subunit 3 pseudogene antikoerper, ARPC3 antikoerper, Arpc3 antikoerper, arpc3.L antikoerper, LOC738738 antikoerper, arpc3 antikoerper, LOC100036831 antikoerper, LOC100341254 antikoerper

Hintergrund: Cellular morphology, adhesion, and motility occur through the reorganization of the actin cytoskeleton. This reorganization of actin filaments occurs through the interactions between actin and actin binding proteins. Actin-binding proteins regulate the polymerization and depolymerization of actin, connect actin-based structures to membranes and to other cytoskeletal elements, power the movement of actin filaments, and cross-link actin filaments into bundles. Actin related proteins (Arp) 2/3 complex is an actin polymerization inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. The Arp2 and Arp3 subunits may nucleate actin polymerization, while the p41-Arc subunit is a WD repeat-containing protein that may regulate both the activity and localization of the Arp2/3 complex. Arp3, p34-Arc, and p21-Arc are localized to the lamellipodia of stationary and locomoting fibroblasts. Both WASP and Abp1p are acidic sequence-containing proteins that activate the Arp2/3 complex. However, WASP binds actin monomers, while the endocytosis-related Abp1p protein binds actin filaments. Thus, Arp2/3 complex may regulate actin polymerization in specific cell locations through interaction with actin binding Arp2/3 activators.

Molekulargewicht: 21 kDa

Pathways: RTK Signalweg, Regulation of Actin Filament Polymerization