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Lamin A/C Antikörper (AA 398-490)

LMNA Reaktivität: Human, Maus, Ratte, Hund, Huhn WB, IF Wirt: Maus Monoclonal 14-LaminAC unconjugated
Produktnummer ABIN968765
  • Target Alle Lamin A/C (LMNA) Antikörper anzeigen
    Lamin A/C (LMNA)
    Bindungsspezifität
    • 10
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 398-490
    Reaktivität
    • 150
    • 84
    • 78
    • 26
    • 15
    • 14
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Huhn
    Wirt
    • 114
    • 44
    • 3
    • 1
    Maus
    Klonalität
    • 109
    • 53
    Monoklonal
    Konjugat
    • 116
    • 11
    • 9
    • 8
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Lamin A/C Antikörper ist unkonjugiert
    Applikation
    • 127
    • 55
    • 52
    • 50
    • 32
    • 29
    • 29
    • 25
    • 13
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Human, Huhn, Hund, Maus, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Lamin A/C aa. 398-490
    Klon
    14-LaminAC
    Isotyp
    IgG1
    Top Product
    Discover our top product LMNA Primärantikörper
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    Related Products: ABIN968535, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Shackleton, Lloyd, Jackson, Evans, Niermeijer, Singh, Schmidt, Brabant, Kumar, Durrington, Gregory, ORahilly, Trembath: "LMNA, encoding lamin A/C, is mutated in partial lipodystrophy." in: Nature genetics, Vol. 24, Issue 2, pp. 153-6, (2000) (PubMed).

    Sullivan, Escalante-Alcalde, Bhatt, Anver, Bhat, Nagashima, Stewart, Burke: "Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy." in: The Journal of cell biology, Vol. 147, Issue 5, pp. 913-20, (1999) (PubMed).

    McKeon, Kirschner, Caput: "Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins." in: Nature, Vol. 319, Issue 6053, pp. 463-8, (1986) (PubMed).

  • Target
    Lamin A/C (LMNA)
    Andere Bezeichnung
    Lamin A/C (LMNA Produkte)
    Synonyme
    CDCD1 antikoerper, CDDC antikoerper, CMD1A antikoerper, CMT2B1 antikoerper, EMD2 antikoerper, FPL antikoerper, FPLD antikoerper, FPLD2 antikoerper, HGPS antikoerper, IDC antikoerper, LDP1 antikoerper, LFP antikoerper, LGMD1B antikoerper, LMN1 antikoerper, LMNC antikoerper, LMNL1 antikoerper, PRO1 antikoerper, Dhe antikoerper, 2459 antikoerper, 74/76 antikoerper, CG6944 antikoerper, D5 antikoerper, DM[[O]] antikoerper, Dm antikoerper, Dm(0) antikoerper, Dm0 antikoerper, Dm1 antikoerper, Dm2 antikoerper, DmLamin antikoerper, DmO antikoerper, Dm[[0]] antikoerper, Dm[[1]] antikoerper, Dm[[2]] antikoerper, Dm[[mit]] antikoerper, Dm[[o]] antikoerper, Dmel\\CG6944 antikoerper, Dmo antikoerper, LAM antikoerper, Lam Dm[[0]] antikoerper, Lam(Dm0) antikoerper, LamDm[[0]] antikoerper, LamDm[[o]] antikoerper, Lam[[Dm0]] antikoerper, Lamin Dm[[0]] antikoerper, jf27 antikoerper, l(2)04643 antikoerper, l(2)25Ec antikoerper, l(2)gdh-7 antikoerper, l(2)gdh7 antikoerper, l(2)jf27 antikoerper, lam antikoerper, lamDm0 antikoerper, lamDm[[0]] antikoerper, lamin antikoerper, lamin Dm0 antikoerper, lamin Dm[[0]] antikoerper, misg antikoerper, nlam antikoerper, cb948 antikoerper, fk66d12 antikoerper, wu:fk66d12 antikoerper, lmna-A antikoerper, fpl antikoerper, idc antikoerper, lfp antikoerper, cddc antikoerper, emd2 antikoerper, fpld antikoerper, hgps antikoerper, ldp1 antikoerper, lmn1 antikoerper, lmnc antikoerper, pro1 antikoerper, cdcd1 antikoerper, cmd1a antikoerper, cmt2b1 antikoerper, lgmd1b antikoerper, Lamin-A antikoerper, lamin-L(III)-like antikoerper, lamin A/C antikoerper, lamin A antikoerper, Lamin antikoerper, lamin A/C L homeolog antikoerper, lamin-L(III)-like antikoerper, LMNA antikoerper, Lmna antikoerper, Lam antikoerper, lmna antikoerper, lmna.L antikoerper, LMINA antikoerper
    Hintergrund
    The nuclear envelope (NE) is a specialized extension of the ER that contains numerous pore complexes interconnected with the nuclear lamina. The nuclear lamina composes the structural framework for the NE and serves as a chromatin anchor site, thus playing a major role in interphase nuclear organization. The major component of nuclear lamina are intermediate filament-like proteins called lamins. In mammalian somatic cells, there are three major lamins, A, B1, and C, and two minor lamins, B2 and A10. A-type lamins (A, A10, and C) are encoded by a single gene and are produced by alternative splicing, while B-type lamins (B1 and B2) are encoded by separate genes. B-type lamins are found in all nucleated somatic cells, while the expression of A-type lamins are developmentally regulated. Mice lacking lamin A show no overt abnormalities until postnatal development when perturbations in nuclear envelop structure correlate with the appearance of muscular dystrophy. In addition, lamin A is mutated in lipodystrophy, a disorder characterized by reduction in subcutaneous adipose tissue. Thus, lamin A and C may be important for nuclear envelope formation during postnatal cell differentiation. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    65 & 74 kDa
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus
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