Transferrin Receptor Antikörper (AA 517- 623)
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- Target Alle Transferrin Receptor (TFRC) Antikörper anzeigen
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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Bindungsspezifität
- AA 517- 623
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Transferrin Receptor Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF)
- Produktmerkmale
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human Transferrin Receptor aa. 517- 623
- Klon
- 2-Transferrin
- Isotyp
- IgG1
- Top Product
- Discover our top product TFRC Primärantikörper
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- Kommentare
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Related Products: ABIN968537, ABIN967389
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store undiluted at -20°C.
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Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA." in: The Journal of biological chemistry, Vol. 270, Issue 49, pp. 29400-6, (1996) (PubMed).
: "The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence." in: Cell, Vol. 39, Issue 2 Pt 1, pp. 267-74, (1985) (PubMed).
: "
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Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA." in: The Journal of biological chemistry, Vol. 270, Issue 49, pp. 29400-6, (1996) (PubMed).
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- Target
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
- Andere Bezeichnung
- Transferrin Receptor (TFRC Produkte)
- Synonyme
- Trfr antikoerper, LOC100219280 antikoerper, tfr antikoerper, cd71 antikoerper, tfr1 antikoerper, trfr antikoerper, CD71 antikoerper, T9 antikoerper, TFR antikoerper, TFR1 antikoerper, TR antikoerper, TRFR antikoerper, p90 antikoerper, 2610028K12Rik antikoerper, AI195355 antikoerper, AI426448 antikoerper, AU015758 antikoerper, E430033M20Rik antikoerper, Mtvr-1 antikoerper, Mtvr1 antikoerper, transferrin receptor antikoerper, TFRC antikoerper, Tfrc antikoerper, tfrc antikoerper
- Hintergrund
- Iron acquisition is a prerequisite for cell proliferation. The transferrin receptor is the primary mode of iron uptake. This receptor mediates iron uptake through internalization and recycling of the iron carrying serum protein transferrin. Binding of transferrin to its receptor causes rapid internalization into an acidic intracellular compartment where iron dissociates from transferrin. Both the receptor and transferrin are then recycled through the exocytic pathway. The transferrin receptor is expressed in most cells and tissues, especially proliferating cells, and the receptor is expressed as a dimer of identical intergral membrane proteins. Transferrin receptor mRNA expression is inversely proportional to iron availability, and this regulation occurs through post-transcriptional control of mRNA stability. Transferrin receptor mRNA contains iron responsive elements (IRE) that are bound by IRE-binding proteins (IRP). The RNA binding of IRPs is dependent on iron levels. Thus, iron deprivation leads to increased RNA binding, which masks the recognition site of endonucleases and stabilizes transferrin receptor mRNA. This antibody is routinely tested by western blot analysis.
- Molekulargewicht
- 85 kDa
- Pathways
- Transition Metal Ion Homeostasis
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