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F11R Antikörper (AA 126-237)

F11R Reaktivität: Human WB, IF Wirt: Maus Monoclonal 43-JAM unconjugated
Produktnummer ABIN968747
  • Target Alle F11R Antikörper anzeigen
    F11R (F11 Receptor (F11R))
    Bindungsspezifität
    • 12
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 126-237
    Reaktivität
    • 67
    • 45
    • 35
    • 10
    • 7
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 57
    • 15
    • 15
    • 1
    Maus
    Klonalität
    • 49
    • 36
    • 1
    Monoklonal
    Konjugat
    • 46
    • 9
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser F11R Antikörper ist unkonjugiert
    Applikation
    • 61
    • 26
    • 20
    • 17
    • 15
    • 13
    • 9
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human JAM aa. 126-237
    Klon
    43-JAM
    Isotyp
    IgG1
    Top Product
    Discover our top product F11R Primärantikörper
  • Kommentare

    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Gupta, Pillarisetti, Ohlstein: "Platelet agonist F11 receptor is a member of the immunoglobulin superfamily and identical with junctional adhesion molecule (JAM): regulation of expression in human endothelial cells and macrophages." in: IUBMB life, Vol. 50, Issue 1, pp. 51-6, (2001) (PubMed).

    Ozaki, Ishii, Arai, Horiuchi, Kawamoto, Suzuki, Kita: "Junctional adhesion molecule (JAM) is phosphorylated by protein kinase C upon platelet activation." in: Biochemical and biophysical research communications, Vol. 276, Issue 3, pp. 873-8, (2000) (PubMed).

    Ozaki, Ishii, Horiuchi, Arai, Kawamoto, Okawa, Iwamatsu, Kita: "Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 2, pp. 553-7, (1999) (PubMed).

    Martìn-Padura, Lostaglio, Schneemann, Williams, Romano, Fruscella, Panzeri, Stoppacciaro, Ruco, Villa, Simmons, Dejana: "Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration." in: The Journal of cell biology, Vol. 142, Issue 1, pp. 117-27, (1998) (PubMed).

  • Target
    F11R (F11 Receptor (F11R))
    Andere Bezeichnung
    JAM-1 (F11R Produkte)
    Synonyme
    CD321 antikoerper, JAM antikoerper, JAM1 antikoerper, JAMA antikoerper, JCAM antikoerper, KAT antikoerper, PAM-1 antikoerper, 9130004G24 antikoerper, AA638916 antikoerper, ESTM33 antikoerper, JAM-1 antikoerper, JAM-A antikoerper, Jcam antikoerper, Jcam1 antikoerper, Ly106 antikoerper, Jam1 antikoerper, F11 receptor antikoerper, F11R antikoerper, F11r antikoerper
    Hintergrund
    Tight junctions (zonulae occludens) are critical to the maintenance of cell polarity and intercellular barriers. Protein components of the tight junctions include actin filaments, symplekin, occludin, ZO-1, ZO-2, and ZO-3. Junctional adhesion molecules, JAM-1, -2, and -3, are a new subfamily in the immunoglobulin (Ig) superfamily that colocalize with these components of tight junctions. JAM-1 was identified through a screen of antibodies that recognizes antigens located at cell-cell contacts. The structure of JAM-1 includes two V-type Ig domains in the extracellular region, two N-glycosylation sites, and a small C-terminal cytoplasmic region. JAM-1 protein is expressed at cell-cell junctions in endothelial and epithelial cells, and antibodies to JAM-1 inhibit spontaneous and chemokine-induced monocyte transmigration through an endothelial cell monolayer. In addition, TNFalpha and IFN-gamma cause redistribution of JAM-1 from intercellular junctions to the cytoplasm. JAM-1 also is the receptor for the platelet membrane protein, F11 antigen, and activation of platelets leads to PKC phosphorylation of JAM-1. Thus, JAM-1 is a junctional adhesion molecule that functions in endothelial, epithelial, and platelet adhesion.
    Molekulargewicht
    38 kDa
    Pathways
    Cell-Cell Junction Organization
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