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Beclin 1 Antikörper (AA 171-291)

BECN1 Reaktivität: Human, Maus, Ratte, Hund, Huhn WB, IF Wirt: Maus Monoclonal 20-Beclin unconjugated
Produktnummer ABIN968744
  • Target Alle Beclin 1 (BECN1) Antikörper anzeigen
    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
    Bindungsspezifität
    • 16
    • 15
    • 15
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 171-291
    Reaktivität
    • 205
    • 89
    • 73
    • 10
    • 9
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Huhn
    Wirt
    • 173
    • 35
    • 2
    Maus
    Klonalität
    • 172
    • 38
    Monoklonal
    Konjugat
    • 94
    • 18
    • 16
    • 15
    • 14
    • 14
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Beclin 1 Antikörper ist unkonjugiert
    Applikation
    • 150
    • 99
    • 62
    • 38
    • 33
    • 27
    • 26
    • 22
    • 20
    • 14
    • 13
    • 4
    • 4
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Maus, Ratte (Rattus), Huhn, Hund
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Beclin aa. 171-291
    Klon
    20-Beclin
    Isotyp
    IgG2a
    Top Product
    Discover our top product BECN1 Primärantikörper
  • Kommentare

    Related Products: ABIN968537, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Liang, Yu, Brown, Levine: "Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function." in: Cancer research, Vol. 61, Issue 8, pp. 3443-9, (2001) (PubMed).

    Liang, Jackson, Seaman, Brown, Kempkes, Hibshoosh, Levine: "Induction of autophagy and inhibition of tumorigenesis by beclin 1." in: Nature, Vol. 402, Issue 6762, pp. 672-6, (2000) (PubMed).

    Aita, Liang, Murty, Pincus, Yu, Cayanis, Kalachikov, Gilliam, Levine: "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21." in: Genomics, Vol. 59, Issue 1, pp. 59-65, (1999) (PubMed).

    Liang, Kleeman, Jiang, Gordon, Goldman, Berry, Herman, Levine: "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein." in: Journal of virology, Vol. 72, Issue 11, pp. 8586-96, (1998) (PubMed).

  • Target
    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
    Andere Bezeichnung
    Beclin (BECN1 Produkte)
    Synonyme
    beclin-1 antikoerper, atg6 antikoerper, vps30 antikoerper, beclin1 antikoerper, Beclin-1 antikoerper, becn1 antikoerper, zgc:73097 antikoerper, ATG6 antikoerper, VPS30 antikoerper, 4921513J16Rik antikoerper, 5430417M23Rik antikoerper, Atg6 antikoerper, beclin 1 antikoerper, beclin 1, autophagy related antikoerper, beclin 1 protein antikoerper, beclin-1 antikoerper, beclin family protein antikoerper, beclin 1, autophagy related L homeolog antikoerper, BECN1 antikoerper, becn1 antikoerper, atg6 antikoerper, CpipJ_CPIJ011087 antikoerper, PTRG_07825 antikoerper, SJAG_01876 antikoerper, Becn1 antikoerper, becn1.L antikoerper
    Hintergrund
    Autophagy is the bulk degradation of cellular proteins through the autophagosomic-lysosomal pathway. This process is important for normal cell growth, and may be disrupted in tumor cells. Beclin is a Bcl-2 binding protein that is homologous to the yeast autophagy gene, apg6/vps30. The structure of beclin includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. However, inhibition of CRM1-dependent nuclear export leads to beclin localization primarily in the nucleus. Mutation of the NES domain of beclin also prevents nuclear export, as well as suppresses beclin-mediated nutrient deprivation-induced autophagy. In addition, these beclin mutants can not inhibit in vitro clonigenicity and in vivo tumorigenicity of MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since overexpression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects. Thus, beclin may be an important component of complexes involved in autophagy. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    61 kDa
    Pathways
    Autophagie
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