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AP4E1 Antikörper (AA 685-793)

AP4E1 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 32-Adaptin epsilon unconjugated
Produktnummer ABIN968712
  • Target Alle AP4E1 Antikörper anzeigen
    AP4E1 (Adaptor-Related Protein Complex 4, epsilon 1 Subunit (AP4E1))
    Bindungsspezifität
    • 1
    • 1
    AA 685-793
    Reaktivität
    Human
    Wirt
    • 1
    • 1
    Maus
    Klonalität
    • 2
    Monoklonal
    Konjugat
    • 2
    Dieser AP4E1 Antikörper ist unkonjugiert
    Applikation
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Adaptin epsilon aa. 685-793
    Klon
    32-Adaptin epsilon
    Isotyp
    IgG1
    Top Product
    Discover our top product AP4E1 Primärantikörper
  • Kommentare

    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Aguilar, Boehm, Gorshkova, Crouch, Tomita, Saito, Ohno, Bonifacino: "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4." in: The Journal of biological chemistry, Vol. 276, Issue 16, pp. 13145-52, (2001) (PubMed).

    DellAngelica, Mullins, Bonifacino: "AP-4, a novel protein complex related to clathrin adaptors." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7278-85, (1999) (PubMed).

    Hirst, Bright, Rous, Robinson: "Characterization of a fourth adaptor-related protein complex." in: Molecular biology of the cell, Vol. 10, Issue 8, pp. 2787-802, (1999) (PubMed).

  • Target
    AP4E1 (Adaptor-Related Protein Complex 4, epsilon 1 Subunit (AP4E1))
    Andere Bezeichnung
    Adaptin epsilon (AP4E1 Produkte)
    Synonyme
    CPSQ4 antikoerper, SPG51 antikoerper, RGD1562199 antikoerper, 2310033A20Rik antikoerper, 9930028M04Rik antikoerper, AV087807 antikoerper, adaptor related protein complex 4 epsilon 1 subunit antikoerper, adaptor-related protein complex 4, epsilon 1 subunit antikoerper, adaptor-related protein complex AP-4, epsilon 1 antikoerper, AP4E1 antikoerper, Ap4e1 antikoerper
    Hintergrund
    Sorting of integral membrane proteins is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (gamma, alpha, sigma, epsilon and beta1, beta2, beta3, beta4 respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, µ4 respectively) and one small chain (sigma1, sigma2, sigma3, sigma4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. AP-4 is associated with non-clathrin coated vesicles in the region of the TGN. This localization is disrupted by brefeldin A, indicating that AP-4 membrane attachment is regulated by small GTPases. The µ4 subunit of the AP-4 complex interacts with tyrosine-based signals on LAMP-2 during targeting to the endosomal-lysosomal system. Thus, AP-4 is a less abundant AP complex that may be important for vesicle trafficking from the Golgi to the endosomal-lysosomal system.
    Molekulargewicht
    127 kDa
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