MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) (AA 180-384)

Details for Product anti-MAPK8IP1 Antibody No. ABIN968696, Anbieter: Anmelden zum Anzeigen
Antigen
  • IB1
  • JIP-1
  • Jip1
  • Prkm8ip
  • Skip
  • mjip-2a
  • JIP1
  • Jip-1
  • Mapk8ip
  • PRKM8IP
  • mitogen-activated protein kinase 8 interacting protein 1
  • MAPK8IP1
  • LOC100344706
  • Mapk8ip1
Epitop
AA 180-384
18
7
5
5
3
2
1
1
1
1
1
1
1
Reaktivität
Maus, Ratte (Rattus)
67
45
39
Wirt
Maus
70
1
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser MAPK8IP1 Antikörper ist unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Fluorescence Microscopy (FM), Western Blotting (WB)
56
31
17
13
9
7
4
3
2
1
1
Optionen
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Immunogen Mouse JIP-1 aa. 180-384
Klon 50-JIP
Isotyp IgG1
Kreuzreaktivität Ratte (Rattus)
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Andere Bezeichnung JIP-1 (MAPK8IP1 Antibody Abstract)
Hintergrund The JNK group of MAPKs is activated by a variety of inflammatory cytokines and environmental stressors. Activated JNK phosphorylates many cellular proteins, such as components of the AP-1 transcription factor complex (c-Jun and ATF-2). JNK-interacting proteins (JIPs) bind JNK, MKK7, MLKs, p190RhoGEF, and the Ste20-related protein kinase HPK1. In mouse, alternative splicing of JIP produces multiple splice variants, JIP-1, JIP-1b, JIP-2a, JIP-2b, and JIP-3. The structure of full length JIP consists of two N-terminal acidic regions, a JNK binding domain (JBD), two proline rich regions (PR), and both an SH3 and a phosphotyrosine-binding domain in the C-terminal region. JIP-1 localizes to the tips of neurites in differentiated PC12 cells, and may interact with JNK, MKK7, and MLK to facilitate formation of the JNK activating complex. IB1 is the rat homologue of JIP-1b, a JIP-1 variant that includes a 47 amino acid insert in the C-terminal region. IB1 is found in the nucleus and cytoplasm, and may function as a transactivator of the GLUT2 gene. Thus, JIP-1 and its related isoforms may have multiple functions that involve specific protein-protein interactions.
Synonyms: JNK Interacting Protein
Molekulargewicht 112 kDa
Kommentare

Related Products: ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20°C.
Bilder des Herstellers
Western Blotting (WB) image for anti-MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) (AA 180-384) (ABIN968696) Western blot analysis of JIP-1 on a mouse cerebellum lysate. Lane 1: 1:250, lane 2: 1...
Produkt verwendet in: Meyer, Liu, Margolis: "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons." in: The Journal of biological chemistry, Vol. 274, Issue 49, pp. 35113-8, 2000 (PubMed).

Bonny, Nicod, Waeber: "IB1, a JIP-1-related nuclear protein present in insulin-secreting cells." in: The Journal of biological chemistry, Vol. 273, Issue 4, pp. 1843-6, 1998 (PubMed).

Dickens, Rogers, Cavanagh, Raitano, Xia, Halpern, Greenberg, Sawyers, Davis: "A cytoplasmic inhibitor of the JNK signal transduction pathway." in: Science (New York, N.Y.), Vol. 277, Issue 5326, pp. 693-6, 1997 (PubMed).