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Synaptophysin Antikörper (AA 205-306)

SYP Reaktivität: Human, Maus, Ratte WB, IF, BI Wirt: Maus Monoclonal 2-Synaptophysin unconjugated
Produktnummer ABIN968694
  • Target Alle Synaptophysin (SYP) Antikörper anzeigen
    Synaptophysin (SYP)
    Bindungsspezifität
    • 13
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 205-306
    Reaktivität
    • 75
    • 55
    • 54
    • 10
    • 10
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 54
    • 34
    • 3
    • 1
    Maus
    Klonalität
    • 51
    • 41
    Monoklonal
    Konjugat
    • 70
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser Synaptophysin Antikörper ist unkonjugiert
    Applikation
    • 70
    • 42
    • 29
    • 21
    • 20
    • 15
    • 15
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat Synaptophysin aa. 205-306
    Klon
    2-Synaptophysin
    Isotyp
    IgG1
    Top Product
    Discover our top product SYP Primärantikörper
  • Kommentare

    Related Products: ABIN968545, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Daly, Sugimori, Moreira, Ziff, Llinás: "Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 11, pp. 6120-5, (2000) (PubMed).

    Thiele, Hannah, Fahrenholz, Huttner: "Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles." in: Nature cell biology, Vol. 2, Issue 1, pp. 42-9, (2000) (PubMed).

    Leube, Kaiser, Seiter, Zimbelmann, Franke, Rehm, Knaus, Prior, Betz, Reinke: "Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA." in: The EMBO journal, Vol. 6, Issue 11, pp. 3261-8, (1988) (PubMed).

  • Target
    Synaptophysin (SYP)
    Andere Bezeichnung
    Synaptophysin (SYP Produkte)
    Synonyme
    syp-B antikoerper, xsypii antikoerper, MGC86267 antikoerper, MRXSYP antikoerper, A230093K24Rik antikoerper, AI848995 antikoerper, Syn antikoerper, p38 antikoerper, Syp1 antikoerper, mrxsyp antikoerper, syp antikoerper, xsypi antikoerper, synaptophysin S homeolog antikoerper, synaptophysin antikoerper, synaptophysin L homeolog antikoerper, synaptophysin a antikoerper, syp.S antikoerper, SYP antikoerper, syp antikoerper, Syp antikoerper, syp.L antikoerper, sypa antikoerper
    Hintergrund
    Synaptophysin is a major integral membrane glycoprotein that was isolated from the presynaptic vesicles of neurons. The structure of synaptophysin includes four transmembrane domains (TMD), an N-temrinal glycosylation site, nine repeats of basic tetrapeptide motifs (GYGP), multiple collagenase sensitive sites (XGP), and several collagen-type tripeptides (GXX). Synaptophysin mRNA is expressed in nervous tissues, as well as many neuroendocrine tumor cell lines. In PC12 cells and brain synaptic vesicles, synaptophysin binds cholesterol, and cholesterol depletion blocks the biogenesis of synaptic-like microvesicles. In addition, synaptophysin binds dynamin in a Ca2+-dependent manner, and injection of peptides that disrupt this interaction decreases neurotransmitter release during high-frequency stimulation of squid neurons. This decrease in neurotransmitter release results from inhibition of synaptophysin-dependent vesicle retrieval. Thus, synaptophysin may have important roles in the biogenesis and recycling of synaptic vesicles. Synaptophysin is an integral membrane glycoprotein with a calculated molecular weight of 33 kD, but has been reported to be observed at 38-42 kD due to glycosylation. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    38 kDa
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity
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