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CNKSR1 Antikörper (AA 10-217)

CNKSR1 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 46-hCNK1 unconjugated
Produktnummer ABIN968649
  • Target Alle CNKSR1 Antikörper anzeigen
    CNKSR1 (Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1))
    Bindungsspezifität
    • 15
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 10-217
    Reaktivität
    • 29
    • 20
    • 14
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 32
    • 3
    Maus
    Klonalität
    • 35
    Monoklonal
    Konjugat
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CNKSR1 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 13
    • 13
    • 10
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human hCNK1 aa. 10-217
    Klon
    46-hCNK1
    Isotyp
    IgG1
  • Kommentare

    Related Products: ABIN968533, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Therrien, Wong, Kwan, Rubin: "Functional analysis of CNK in RAS signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13259-63, (1999) (PubMed).

    Therrien, Wong, Rubin: "CNK, a RAF-binding multidomain protein required for RAS signaling." in: Cell, Vol. 95, Issue 3, pp. 343-53, (1998) (PubMed).

  • Target
    CNKSR1 (Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1))
    Andere Bezeichnung
    hCNK1 (CNKSR1 Produkte)
    Synonyme
    zgc:77200 antikoerper, CNKSR1 antikoerper, cnk antikoerper, ksr antikoerper, cnk1 antikoerper, CNK antikoerper, CNK1 antikoerper, KSR antikoerper, BC037758 antikoerper, connector enhancer of kinase suppressor of Ras 1 antikoerper, connector enhancer of kinase suppressor of Ras 1 L homeolog antikoerper, cnksr1 antikoerper, CNKSR1 antikoerper, cnksr1.L antikoerper, Cnksr1 antikoerper
    Hintergrund
    Proteins of the Ras superfamily play critical roles in the control of normal and neoplastic proliferation. These proteins relay signals from Tyr-kinases at the plasma membrane to the nucleus via a network of Ser/Thr kinases that includes the MAP kinase (Raf-MEK-ERK) pathway. Kinase suppressor of Ras (KSR-1) was discovered in Drosophila in a genetic screen that identified mutations that suppress constitutively active Ras mutants. Connector enhancer of KSR (CNK) was found in a similar screen to identify mutations that enhance the KSR- dependent phenotype. Drosophila CNK contains a sterile alpha motif (SAM), a conserved region in CNK (CRIC), and a PDZ domain in the N-terminal region, a proline-rich and a plecstrin homology (PH) domain in the central region, and a C-terminal Pro-rich domain. The human homologue of CNK (hCNK1) contains similar N-terminal and central domains, but is 713 amino acids in length compared to 1557 amino acids for Drosophila CNK. In Drosophila, the N-terminal region of CNK facilitates binding to RAS, while the C-terminal region inhibits RAS- and RAF-dependent signaling. Thus, CNK may be important for regulation of both RAS- and RAF-dependent signaling.
    Synonyms: Connector enhancer of KSR
    Molekulargewicht
    79-100 kDa
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