BCLAF1 Antikörper (BCL2-Associated Transcription Factor 1) (AA 318-439)

Details for Product anti-BCLAF1 Antibody No. ABIN968645, Anbieter: Anmelden zum Anzeigen
Antigen
  • BCLAF1
  • btf
  • bk211l9.1
  • DKFZp468F0113
  • BTF
  • bK211L9.1
  • 2610102K23Rik
  • 2700025J07Rik
  • 2810454G14Rik
  • 5730534O06Rik
  • AI450190
  • AW556225
  • Btf
  • mKIAA0164
  • Aa2-041
  • Fam54a
  • Mtfr2
  • BCL2-associated transcription factor 1
  • BCLAF1
  • bclaf1
  • LOC100231845
  • LOC100339738
  • LOC100351429
  • Bclaf1
Alternativen
anti-Human BCLAF1 Antikörper für ELISA
Epitop
AA 318-439
14
9
9
7
5
4
3
2
1
1
1
1
Reaktivität
Human
93
34
25
10
4
4
4
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3
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2
2
2
2
1
1
1
Wirt
Maus
75
19
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser BCLAF1 Antikörper ist unkonjugiert
4
4
4
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2
2
2
2
1
1
1
1
1
1
1
1
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1
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1
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1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
76
40
38
21
16
13
9
5
1
1
Optionen
Hersteller
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Immunogen Human Btf [L] aa. 318-439
Klon 5-Btf
Isotyp IgG1
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Andere Bezeichnung Btf (BCLAF1 Antibody Abstract)
Hintergrund Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic programs in virus-infected cells regulate viral replication and pathogenesis. However, viruses, such as human adenovirus, have evolved methods of circumventing these programs. The adenovirus E1B encodes a 19 kDa protein (E1B 19K) that, similar to Bcl-2, suppresses apoptosis via interactions with intracellular proteins. Btf (Bcl-2 associated Transcription Factor) interacts with E1B 19K, Bcl-2, and Bcl-xL. Two forms of Btf, Btf [L] and Btf [S], differ due to a 49 amino acid deletion in the C-terminal region of Btf [S]. Both forms contain putative basic zipper-like (bZIP) and Myb-like DNA-binding domains. In vitro, Btf binds DNA and represses transcriptional activity. Cotransfection of E1B 19K, Bcl-2, Bcl-xL, and Btf results in the cytoplasmic sequestration of Btf and inhibition of its transcriptional repression activity. Overexpression of Btf induces apoptosis, which is inhibited by E1B 19K. Thus, Btf is an important death-promoting transcriptional factor, which is regulated by anti-apoptotic members of the Bcl-2 family.
Synonyms: Bcl-2 associated Transcription Factor
Molekulargewicht 150 kDa
Pathways Positive Regulation of Response to DNA Damage Stimulus
Kommentare

Related Products: ABIN968537, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20° C.
Bilder des Herstellers
Western Blotting (WB) image for anti-BCLAF1 Antikörper (BCL2-Associated Transcription Factor 1) (AA 318-439) (ABIN968645) Western blot analysis of Btf on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB...
Immunofluorescence (IF) image for anti-BCLAF1 Antikörper (BCL2-Associated Transcription Factor 1) (AA 318-439) (ABIN968645) Immunofluorescence staining of human endothelial cells.
Produkt verwendet in: Kasof, Goyal, White: "Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins." in: Molecular and cellular biology, Vol. 19, Issue 6, pp. 4390-404, 1999 (PubMed).