CTNND2 Antikörper (AA 85-194)

Produktnummer ABIN968579

Produktdetails anti-CTNND2 Antikörper

Target: CTNND2 (Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein (CTNND2))

Bindungsspezifität: AA 85-194

Reaktivität: Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CTNND2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse delta-Catenin aa. 85-194

Klon: 30-delta

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-CTNND2 Antikörper (ABIN968579)

Akins, Greer: "Axon behavior in the olfactory nerve reflects the involvement of catenin-cadherin mediated adhesion." in: The Journal of comparative neurology, Vol. 499, Issue 6, pp. 979-89, (2007) (PubMed).

Izawa, Nishizawa, Ohtakara, Inagaki: "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5345-50, (2002) (PubMed).

Laura, Witt, Held, Gerstner, Deshayes, Koehler, Kosik, Sidhu, Lasky: "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12906-14, (2002) (PubMed).

Ho, Zhou, Medina, Goto, Jacobson, Bhide, Kosik: "delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development." in: The Journal of comparative neurology, Vol. 420, Issue 2, pp. 261-76, (2000) (PubMed).

Lu, Paredes, Medina, Zhou, Cavallo, Peifer, Orecchio, Kosik: "delta-catenin, an adhesive junction-associated protein which promotes cell scattering." in: The Journal of cell biology, Vol. 144, Issue 3, pp. 519-32, (1999) (PubMed).

Details zu CTNND2

Target: CTNND2 (Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein (CTNND2))

Andere Bezeichnung: delta-Catenin (CTNND2 Produkte)

Synonyme: CTNND2 antikoerper, Catnd2 antikoerper, Nprap antikoerper, neurojugin antikoerper, GT24 antikoerper, NPRAP antikoerper, ctnnd2 antikoerper, si:dkey-40c17.4 antikoerper, catenin delta 2 antikoerper, delta-catenin antikoerper, catenin delta-2 antikoerper, catenin (cadherin associated protein), delta 2 antikoerper, catenin (cadherin-associated protein), delta 2b antikoerper, CTNND2 antikoerper, BACOIKO001_27 antikoerper, LOC100070792 antikoerper, Ctnnd2 antikoerper, ctnnd2b antikoerper

Hintergrund: The catenins (alpha, beta, gamma, delta, p120[ctn]) are cytoplasmic proteins that are related to the Drosophila Armadillo protein. Catenins may have dual roles since they are components of cell-cell adherens junctions and can translocate to the nucleus after stimulation of the Wingless (Wnt-1 homolog) signaling pathway. alpha-Catenin has two subtypes: alphaE-Catenin, which is expressed ubiquitously, and alphaN-Catenin, which is expressed in the nervous system. beta-Catenin binds to the cytoplasmic tail of E-Cadherin at adherens junctions and has been implicated in Wnt-1 signaling. gamma-Catenin is associated with desmoglein in desmosomes and is closely related to beta-Catenin. p120[ctn] is related to both beta- and gamma-catenin and is a substrate of tyrosine kinases localized at adherens junctions. delta-catenin was identified by its ability to bind the Alzheimer's disease-related protein, presenilin-1. It is most closely related to p120[ctn] and the desmosomal protein, p0071. It contains 10 Armadillo (Arm) repeats, as compared to the 13 Arm repeats found in beta-Catenin. delta-Catenin is expressed at high levels in the developing nervous system, where it may be involved in neuronal progenitor cell migration and dendrite development.

Molekulargewicht: 160 kDa