SLC3A2 Antikörper (AA 9-204)

Produktnummer ABIN968570

Produktdetails anti-SLC3A2 Antikörper

Target: SLC3A2 (Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2))

Bindungsspezifität: AA 9-204

Reaktivität: Chemical

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SLC3A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat 4F2 hc aa. 9-204

Klon: 30-CD98HC

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968548

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-SLC3A2 Antikörper (ABIN968570)

Nakamura, Sato, Yang, Miyagawa, Harasaki, Tomita, Matsuoka, Noma, Iwai, Minato: "4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer." in: The Journal of biological chemistry, Vol. 274, Issue 5, pp. 3009-16, (1999) (PubMed).

Tsurudome, Ito, Takebayashi, Okumura, Nishio, Kawano, Kusagawa, Komada, Ito: "Cutting edge: primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 5, pp. 2462-6, (1999) (PubMed).

Kanai, Segawa, Miyamoto, Uchino, Takeda, Endou: "Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 23629-32, (1998) (PubMed).

Fenczik, Sethi, Ramos, Hughes, Ginsberg: "Complementation of dominant suppression implicates CD98 in integrin activation." in: Nature, Vol. 390, Issue 6655, pp. 81-5, (1997) (PubMed).

Details zu SLC3A2

Target: SLC3A2 (Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2))

Andere Bezeichnung: CD98HC (SLC3A2 Produkte)

Synonyme: 4F2 antikoerper, 4F2HC antikoerper, 4T2HC antikoerper, CD98 antikoerper, CD98HC antikoerper, MDU1 antikoerper, NACAE antikoerper, Mdu1 antikoerper, MGC53951 antikoerper, slc3a2 antikoerper, MGC53965 antikoerper, SLC3A2 antikoerper, AI314110 antikoerper, Cd98 antikoerper, Ly-10 antikoerper, Ly-m10 antikoerper, Ly10 antikoerper, Mgp-2hc antikoerper, fc65h12 antikoerper, wu:fc65h12 antikoerper, id:ibd1327 antikoerper, sb:cb519 antikoerper, wu:fe14a07 antikoerper, wu:fq18d12 antikoerper, zgc:55813 antikoerper, solute carrier family 3 member 2 antikoerper, solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog antikoerper, solute carrier family 3 (amino acid transporter heavy chain), member 2 S homeolog antikoerper, solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 antikoerper, solute carrier family 3 (amino acid transporter heavy chain), member 2a antikoerper, solute carrier family 3 (amino acid transporter heavy chain), member 2b antikoerper, SLC3A2 antikoerper, Slc3a2 antikoerper, slc3a2.L antikoerper, slc3a2.S antikoerper, slc3a2a antikoerper, slc3a2b antikoerper

Substanzklasse: Chemical

Hintergrund: 4F2 antigen (CD98) was identified as a heterodimer consisting of an 80 kDa type II glycosylated integral membrane protein 4F2 heavy chain (4F2 hc) linked by disulfide bonds to a hydrophobic, non-glycosylated, 37 kDa protein 4F2 light chain (4F2 lc). The 4F2 hc colocalizes with cadherins at cell adhesion sites and is required for the intracellular targeting of 4F2 heterodimers. 4F2 hc also associates with beta1 integrins and overexpression of 4F2 reverses the suppression of beta1 integrin activation caused by overexpression of beta1 cytoplasmic domains. 4F2 has also been identified as a fusion regulatory protein FRP-1, since anti-FRP-1 antibodies can induce HIV-mediated cell fusion via an integrin system. 4F2 heterodimers are also important for activation of amino acid transport. 4F2 hc is 30% homologous with the amino acid transport activator D2/rBAT and expression of 4F2 hc in Xenopus oocytes induces system y+L amino acid transport. Thus, 4F2 hc may participate in intracellular trafficking and activation of amino acid transporters, as well as in the regulation of integrin signaling.
Synonyms: 4F2 hc

Molekulargewicht: 80 kDa