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AP2M1 Antikörper (AA 110-230)

AP2M1 Reaktivität: Human, Maus, Ratte WB, IF Wirt: Maus Monoclonal 31-AP50 unconjugated
Produktnummer ABIN968487
  • Target Alle AP2M1 Antikörper anzeigen
    AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))
    Bindungsspezifität
    • 16
    • 15
    • 11
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 110-230
    Reaktivität
    • 77
    • 48
    • 31
    • 4
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 85
    • 8
    • 2
    Maus
    Klonalität
    • 79
    • 16
    Monoklonal
    Konjugat
    • 36
    • 8
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser AP2M1 Antikörper ist unkonjugiert
    Applikation
    • 62
    • 35
    • 26
    • 26
    • 15
    • 14
    • 12
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte (Rattus), Human
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse AP50/mu2 aa. 110-230
    Klon
    31-AP50
    Isotyp
    IgG1
    Top Product
    Discover our top product AP2M1 Primärantikörper
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    Related Products: ABIN968545, ABIN967389, ABIN968533

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Vecchi, Polo, Poupon, van de Loo, Benmerah, Di Fiore: "Nucleocytoplasmic shuttling of endocytic proteins." in: The Journal of cell biology, Vol. 153, Issue 7, pp. 1511-7, (2001) (PubMed).

    Ohno, Stewart, Fournier, Bosshart, Rhee, Miyatake, Saito, Gallusser, Kirchhausen, Bonifacino: "Interaction of tyrosine-based sorting signals with clathrin-associated proteins." in: Science (New York, N.Y.), Vol. 269, Issue 5232, pp. 1872-5, (1995) (PubMed).

  • Target
    AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))
    Andere Bezeichnung
    AP50 (AP2M1 Produkte)
    Synonyme
    AP50 antikoerper, CLAPM1 antikoerper, mu2 antikoerper, Ap50 antikoerper, Clapm1 antikoerper, cb34 antikoerper, Ap2m1 antikoerper, dpy-23 antikoerper, sb:cb34 antikoerper, zgc:55711 antikoerper, zgc:85653 antikoerper, wu:fa97a10 antikoerper, ap2m1-a antikoerper, ap2m1 antikoerper, zgc:56643 antikoerper, AP2M1 antikoerper, adaptor related protein complex 2 mu 1 subunit antikoerper, adaptor-related protein complex 2, mu 1 subunit antikoerper, adaptor-related protein complex 2, mu 1 subunit, a antikoerper, adaptor related protein complex 2 mu 1 subunit L homeolog antikoerper, adaptor-related protein complex 2, mu 1 subunit, b antikoerper, AP-2 complex subunit mu-1 antikoerper, clathrin coat assembly protein AP50 antikoerper, clathrin coat assembly protein ap50 antikoerper, AP2M1 antikoerper, Ap2m1 antikoerper, ap2m1a antikoerper, ap2m1.L antikoerper, ap2m1b antikoerper, ap2m1 antikoerper, cgd8_950 antikoerper, PY06523 antikoerper, PVX_118455 antikoerper, PVX_123590 antikoerper, CpipJ_CPIJ003697 antikoerper
    Hintergrund
    Sorting of integral membrane proteins is mediated vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (gamma, alpha, delta, epsilon, and beta1, beta2, beta3, beta4 respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, µ4 respectively) and one small chain ( sigma1, sigma2, sigma3, sigma4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2, µ2 (AP50) interacts with integral membrane proteins via binding to tyrosine-based signals with the canonical motif YXXPhi. In addition, AP50/µ2 is required for both the assembly and the proton transport activity of vacuolar (H+)-ATPases in clathrin coated vesicles. Thus, AP50/µ2 may be involved in targeting integral membrane proteins that are sorted based on tyrosine-based signals and involved in assembly of functional ion channels associated with clathrin coated vesicles.
    Molekulargewicht
    50 kDa
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom
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