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AP3D1 Antikörper (AA 627-731)

AP3D1 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 18-Adaptin delta unconjugated
Produktnummer ABIN968477
  • Target Alle AP3D1 Antikörper anzeigen
    AP3D1 (Adaptor-Related Protein Complex 3, delta 1 Subunit (AP3D1))
    Bindungsspezifität
    • 4
    • 1
    • 1
    • 1
    • 1
    AA 627-731
    Reaktivität
    • 11
    • 1
    • 1
    • 1
    Human
    Wirt
    • 7
    • 4
    Maus
    Klonalität
    • 11
    Monoklonal
    Konjugat
    • 11
    Dieser AP3D1 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 9
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Adaptin delta aa. 627-731
    Klon
    18-Adaptin delta
    Isotyp
    IgG1
  • Kommentare

    Related Products: ABIN968535, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Blumstein, Faundez, Nakatsu, Saito, Ohno, Kelly: "The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 20, pp. 8034-42, (2001) (PubMed).

    Zhen, Jiang, Feng, Bright, Peden, Seymour, Novak, Elliott, Gorin, Robinson, Swank: "Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse." in: Blood, Vol. 94, Issue 1, pp. 146-55, (1999) (PubMed).

    Le Borgne, Alconada, Bauer, Hoflack: "The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins." in: The Journal of biological chemistry, Vol. 273, Issue 45, pp. 29451-61, (1998) (PubMed).

    Ooi, Moreira, DellAngelica, Poy, Wassarman, Bonifacino: "Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet." in: The EMBO journal, Vol. 16, Issue 15, pp. 4508-18, (1997) (PubMed).

  • Target
    AP3D1 (Adaptor-Related Protein Complex 3, delta 1 Subunit (AP3D1))
    Andere Bezeichnung
    Adaptin delta (AP3D1 Produkte)
    Synonyme
    wu:fj51g01 antikoerper, si:ch211-129c21.6 antikoerper, ADTD antikoerper, hBLVR antikoerper, AA407035 antikoerper, Ap3d antikoerper, Bolvr antikoerper, mBLVR1 antikoerper, mh antikoerper, mocha antikoerper, BLVR antikoerper, adaptor-related protein complex 3, delta 1 subunit antikoerper, AP-3 complex subunit delta-1 antikoerper, adaptor related protein complex 3 delta 1 subunit antikoerper, ap3d1 antikoerper, EDI_172030 antikoerper, EHI_158840 antikoerper, Tsp_04773 antikoerper, AP3D1 antikoerper, Ap3d1 antikoerper
    Hintergrund
    Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1 through AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (gamma, alpha, delta, epsilon and beta1, beta2, beta3, beta4, respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, or µ4) and one small chain (sigma1, sigma2, sigma3, or sigma4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. In the AP-3 complex, adaptin delta contains an N-terminal head domain that has 25% identity with adaptins alpha and gamma, while its C-terminal hinge and ear domains are two-fold larger and more divergent as compared to the same domains in adaptins alpha and gamma. Adaptin delta is widely expressed and its mutation results in protein storage deficiencies within lysosomal-related organelles in platelets, melansomes, and synaptic vesicles. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    160 kDa
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