GS28 Antikörper (AA 3-108)

Produktnummer ABIN968404

Produktdetails anti-GS28 Antikörper

Target: GS28 (GOSR1) (Golgi SNAP Receptor Complex Member 1 (GOSR1))

Bindungsspezifität: AA 3-108

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GS28 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Maus, Human

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat GS28 aa. 3-108

Klon: 1-GS28

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-GS28 Antikörper (ABIN968404)

Loh, Peter, Subramaniam, Hong: "Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus." in: Journal of cell science, Vol. 118, Issue Pt 6, pp. 1209-22, (2005) (PubMed).

Hamza, Prohaska, Gitlin: "Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1215-20, (2003) (PubMed).

Muller, Shorter, Newman, Deinhardt, Sagiv, Elazar, Warren, Shima: "Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion." in: The Journal of cell biology, Vol. 157, Issue 7, pp. 1161-73, (2002) (PubMed).

Lanoix, Ouwendijk, Stark, Szafer, Cassel, Dejgaard, Weiss, Nilsson: "Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1." in: The Journal of cell biology, Vol. 155, Issue 7, pp. 1199-212, (2001) (PubMed).

Subramaniam, Loh, Hong: "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex." in: The Journal of biological chemistry, Vol. 272, Issue 41, pp. 25441-4, (1997) (PubMed).

Subramaniam, Peter, Philp, Wong, Hong: "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport." in: Science (New York, N.Y.), Vol. 272, Issue 5265, pp. 1161-3, (1996) (PubMed).

Details zu GS28

Target: GS28 (GOSR1) (Golgi SNAP Receptor Complex Member 1 (GOSR1))

Andere Bezeichnung: GS28 (GOSR1 Produkte)

Synonyme: CG7700 antikoerper, Dmel\\CG7700 antikoerper, FSG28 antikoerper, GOS28 antikoerper, dgos28 antikoerper, GOSR1 antikoerper, gosr1 antikoerper, zgc:112064 antikoerper, GOLIM2 antikoerper, GOS-28 antikoerper, GOS28/P28 antikoerper, GS28 antikoerper, P28 antikoerper, AI414660 antikoerper, AI426320 antikoerper, BB145494 antikoerper, GOSRI antikoerper, p28 antikoerper, Gos28 antikoerper, v-SNARE antikoerper, Golgi SNARE, 28 kDa antikoerper, golgi SNAP receptor complex member 1 antikoerper, Golgi SNAP receptor complex member 1 antikoerper, Gos28 antikoerper, GOSR1 antikoerper, gosr1 antikoerper, CpipJ_CPIJ014329 antikoerper, PAAG_02888 antikoerper, Tsp_07481 antikoerper, Gosr1 antikoerper, gos-28 antikoerper

Hintergrund: Most vesicular fusion events require the function of N-ethylmaleimide-sensitive factor (NSF) and the soluble NSF attachment proteins (SNAPs). Their function is dependent upon the SNAP receptor (SNARE) family of proteins. The specificity of vesicle docking and fusion is mediated by specific interactions between v-SNAREs on vesicles and t-SNAREs on target membranes. GS28 (Golgi SNARE with a size of 28 kDa) is a SNARE that associates with the cis-Golgi and participates in trafficking between the ER and the Golgi and between Golgi compartments. The majority of GS28, the first 230 and 250 aa, is thought to be anchored to the membrane via the C-terminal hydrophobic tail, which is formed by the remaining 20 aa. GS28 and syntaxin 5, another SNARE, exist as a protein complex in the Golgi and this complex is important for the function of both proteins in ER-Golgi transport. The GS28/syntaxin 5 complex can be dissociated by alpha-SNAP and NSF. In addition, GS28 is thought to interact with alpha-SNAP when the GS28/syntaxin 5 complex is dissociated. Thus, GS28 is a SNARE protein that mediates, in complex with syntaxin 5, transport within the Golgi and between Golgi and ER. This antibody is routinely tested by western blot analysis.

Molekulargewicht: 28 kDa