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ROCK1 Antikörper (AA 906-1012)

ROCK1 Reaktivität: Human, Maus, Ratte WB, IF Wirt: Maus Monoclonal 46-ROCK unconjugated
Produktnummer ABIN968387
  • Target Alle ROCK1 Antikörper anzeigen
    ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
    Bindungsspezifität
    • 16
    • 16
    • 15
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 906-1012
    Reaktivität
    • 79
    • 59
    • 57
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 71
    • 9
    Maus
    Klonalität
    • 58
    • 22
    Monoklonal
    Konjugat
    • 39
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser ROCK1 Antikörper ist unkonjugiert
    Applikation
    • 69
    • 27
    • 26
    • 20
    • 17
    • 15
    • 13
    • 12
    • 11
    • 8
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Human, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse ROCK-I aa. 906-1012
    Klon
    46-ROCK
    Isotyp
    IgG1
    Top Product
    Discover our top product ROCK1 Primärantikörper
  • Kommentare

    Related Products: ABIN967389, ABIN968542

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Pawlak, Helfman: "Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts." in: Molecular biology of the cell, Vol. 13, Issue 1, pp. 336-47, (2002) (PubMed).

    Wang, Eto, Steers, Somlyo, Somlyo: "RhoA-mediated Ca2+ sensitization in erectile function." in: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 30614-21, (2002) (PubMed).

    Sahai, Olson, Marshall: "Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility." in: The EMBO journal, Vol. 20, Issue 4, pp. 755-66, (2001) (PubMed).

    Ishizaki, Maekawa, Fujisawa, Okawa, Iwamatsu, Fujita, Watanabe, Saito, Kakizuka, Morii, Narumiya: "The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase." in: The EMBO journal, Vol. 15, Issue 8, pp. 1885-93, (1996) (PubMed).

    Nakagawa, Fujisawa, Ishizaki, Saito, Nakao, Narumiya: "ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice." in: FEBS letters, Vol. 392, Issue 2, pp. 189-93, (1996) (PubMed).

  • Target
    ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
    Andere Bezeichnung
    ROCK-I (ROCK1 Produkte)
    Synonyme
    LOC100229794 antikoerper, CG9774 antikoerper, DROK antikoerper, DRhk antikoerper, DRok antikoerper, Dmel\\CG9774 antikoerper, Drok antikoerper, ROCK antikoerper, ROCK-1 antikoerper, ROCK1 antikoerper, ROK antikoerper, ROKalpha/beta antikoerper, Rhk antikoerper, RhoK antikoerper, Rock antikoerper, Rok antikoerper, dROK antikoerper, dRok antikoerper, drok antikoerper, 1110055K06Rik antikoerper, Rock-I antikoerper, P160Rock antikoerper, ROCK-I antikoerper, P160ROCK antikoerper, p160ROCK antikoerper, Rho associated coiled-coil containing protein kinase 1 antikoerper, Rho kinase antikoerper, Rho-associated coiled-coil containing protein kinase 1 antikoerper, Rho-associated, coiled-coil containing protein kinase 1 antikoerper, ROCK1 antikoerper, Rok antikoerper, Rock1 antikoerper, rock1 antikoerper
    Hintergrund
    ROCK-I is a Rho-associated serine/threonine kinase isozyme that mediates RhoA-induced assembly of focal adhesions and actin stress fibers. It contains an N-terminal kinase domain, a central 600 amino acid long coiled-coil region, a C-terminal pleckstrin homology region (PH) and a Cys-rich zinc finger motif. The ROCK-I kinase domain is approximately 90% identical to that of ROCK-II. ROCK-I binds GTP-bound Rho through a Rho-binding domain (RBD). As a result, the kinase activity of ROCK-I is moderately stimulated. The ROCK isozymes regulate cell contractility through phosphorylation of the myosin light chain. This effect results from either the inhibition of the myosin phosphatase or by direct phosphorylation of the myosin light chain, thus bypassing the myosin light chain kinase. In addition, ROCK-I activates the ubiquitously expressed Na-H exchanger (NHE1) via a number of mechanisms including RhoA. NHE1 may mediate ROCK-I-induced changes in the actin cytoskeleton. Therefore, ROCK-I plays an important role in the regulation of focal adhesion and stress fiber formation.
    Synonyms: ROKbeta
    Molekulargewicht
    160 kDa
    Pathways
    Microtubule Dynamics, WNT Signalweg, M Phase, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
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