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ITGA3 Antikörper (AA 110-325)

ITGA3 Reaktivität: Maus, Ratte, Hund WB, IF Wirt: Maus Monoclonal 42-CD49c unconjugated
Produktnummer ABIN968338
  • Target Alle ITGA3 Antikörper anzeigen
    ITGA3 (Integrin, alpha 3 (ITGA3))
    Bindungsspezifität
    • 16
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 110-325
    Reaktivität
    • 58
    • 36
    • 17
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus, Ratte, Hund
    Wirt
    • 46
    • 24
    • 3
    • 1
    Maus
    Klonalität
    • 50
    • 27
    Monoklonal
    Konjugat
    • 36
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITGA3 Antikörper ist unkonjugiert
    Applikation
    • 44
    • 36
    • 22
    • 14
    • 13
    • 9
    • 9
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte (Rattus), Hund
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse VLA-3alpha aa. 110-325
    Klon
    42-CD49c
    Isotyp
    IgG1
    Top Product
    Discover our top product ITGA3 Primärantikörper
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    Related Products: ABIN968547, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Takeuchi, Hirano, Tsuji, Osawa, Irimura: "cDNA cloning of mouse VLA-3 alpha subunit." in: Journal of cellular biochemistry, Vol. 57, Issue 2, pp. 371-7, (1995) (PubMed).

    Takada, Murphy, Pil, Chen, Ginsberg, Hemler: "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen." in: The Journal of cell biology, Vol. 115, Issue 1, pp. 257-66, (1991) (PubMed).

  • Target
    ITGA3 (Integrin, alpha 3 (ITGA3))
    Andere Bezeichnung
    CD49c (ITGA3 Produkte)
    Synonyme
    CD49C antikoerper, GAP-B3 antikoerper, GAPB3 antikoerper, ILNEB antikoerper, MSK18 antikoerper, VCA-2 antikoerper, VL3A antikoerper, VLA3a antikoerper, ITGA3 antikoerper, AA407068 antikoerper, integrin subunit alpha 3 antikoerper, integrin subunit alpha 3 S homeolog antikoerper, integrin alpha 3 antikoerper, ITGA3 antikoerper, itga3.S antikoerper, Itga3 antikoerper
    Hintergrund
    Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large alpha chain that is non-covalently associated with a smaller beta chain which defines the integrin subfamilies. VLA-3 (Very Late Antigen-3), a member of the integrin superfamily, exhibits elevated expression on B lymphocytes, but is also found on monocytes, platelets, and hematopoietic progenitor cells. A heterodimer of alpha3 (CD49c) and beta1 (CD29) subunits, VLA is a receptor for laminin, fibronectin, and collagen. The alpha3 chain contains a large extracellular domain with three putative metal-binding sequences, a transmembrane domain, and a short cytoplasmic tail. Differing requirements for divalent cations and the influence of RGD peptides results in multiple ligand-binding mechanisms for VLA-3. Although its expression is restricted in normal tissues, VLA-3 is found on a variety of cultured tumor cells. In addition, levels of VLA-3 have been shown to correlate with the degree of invasiveness of malignant melanoma cells. Thus, VLA-3 mediates intercellular adhesion and cell migration in normal and, possibly, cancerous cell types.
    Synonyms: Integrin alpha3, VLA-3alpha
    Molekulargewicht
    135 kDa
    Pathways
    CXCR4-mediated Signaling Events, Integrin Complex
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