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MAP4 Antikörper (AA 583-702)

MAP4 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 18-MAP4 unconjugated
Produktnummer ABIN968326
  • Target Alle MAP4 Antikörper anzeigen
    MAP4 (Microtubule-Associated Protein 4 (MAP4))
    Bindungsspezifität
    • 15
    • 15
    • 9
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 583-702
    Reaktivität
    • 69
    • 33
    • 33
    • 1
    Human
    Wirt
    • 68
    • 3
    Maus
    Klonalität
    • 68
    • 3
    Monoklonal
    Konjugat
    • 33
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser MAP4 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 29
    • 29
    • 23
    • 18
    • 14
    • 10
    • 9
    • 7
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human MAP4 aa. 583-702
    Klon
    18-MAP4
    Isotyp
    IgG1
    Top Product
    Discover our top product MAP4 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Drewes, Ebneth, Preuss, Mandelkow, Mandelkow: "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption." in: Cell, Vol. 89, Issue 2, pp. 297-308, (1997) (PubMed).

    Ulitzur, Humbert, Pfeffer: "Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 10, pp. 5084-9, (1997) (PubMed).

    Chapin, Lue, Yu, Bulinski: "Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains." in: Biochemistry, Vol. 34, Issue 7, pp. 2289-301, (1995) (PubMed).

  • Target
    MAP4 (Microtubule-Associated Protein 4 (MAP4))
    Andere Bezeichnung
    MAP4 (MAP4 Produkte)
    Synonyme
    XMAP4 antikoerper, mtap4 antikoerper, AA407148 antikoerper, MAP-4 antikoerper, Mtap-4 antikoerper, Mtap4 antikoerper, microtubule associated protein 4 antikoerper, microtubule associated protein 4 L homeolog antikoerper, microtubule-associated protein 4 antikoerper, MAP4 antikoerper, map4.L antikoerper, Map4 antikoerper
    Hintergrund
    The microtubule (MT) cytoskeleton functions in cytoplasmic organization, cellular movement, determination of cell polarity, intracellular transport, and chromosome segregation. Dynamic instability, continuous cycles of MT assembly (stabilization) and disassembly, mediates MT participation in these events. The function of MTs, particularly stabilization, is regulated by MT-associated proteins (MAPs). A subfamily of MAPs, called AP-MAPs (assembly promoting MAPs), includes tau, MAP2, and MAP4. These proteins are classified as type II MAPs and contain a C-terminal MT binding domain with 3 to 5 imperfect repeats of an 18 amino acid motif. While tau and MAP2 are specifically expressed in neuronal cells, MAP4 is the major MAP of nonneuronal mammalian cells. MAP activity and interaction with MTs are regulated by MARK (MAP/MT affinity-regulating kinase) and mapmodulin. MARK-mediated phosphorylation of MAPs on their homologous KXGS motifs results in detachment of MAPs from MTs and MT disruption. In addition, mapmodulin tightly interacts with the MT-binding domains of MAPs and hinders MAP binding to MTs. Thus, MAP4 is a highly regulated type II MAP that controls MT assembly and disassembly.
    Molekulargewicht
    200-220 kDa
    Pathways
    p53 Signalweg, Microtubule Dynamics
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