MAP2K5 Antikörper (Mitogen-Activated Protein Kinase Kinase 5) (AA 13-188)

Details for Product anti-MAP2K5 Antibody No. ABIN968272, Anbieter: Anmelden zum Anzeigen
Antigen
  • Mek5
  • HsT17454
  • MAPKK5
  • MEK5
  • PRKMK5
  • AI324775
  • AI428457
  • Mapkk5
  • Prkmk5
  • fb73f02
  • wu:fb73f02
  • zgc:172137
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
  • ATMAP2K_ALPHA
  • ATMEK5
  • ATMKK5
  • MAP KINASE KINASE 5
  • MAP kinase kinase 5
  • MAP2K_A
  • mitogen activated protein kinase kinase 5
  • mitogen-activated protein kinase kinase 5
  • Map2k5
  • MAP2K5
  • map2k5
  • MKK5
Epitop
AA 13-188
33
32
15
15
15
15
14
11
10
9
6
6
5
4
4
4
3
3
2
2
1
1
1
1
1
1
1
Reaktivität
Human
169
90
83
11
7
7
6
4
3
3
3
3
2
2
2
2
1
1
Wirt
Maus
165
15
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser MAP2K5 Antikörper ist unkonjugiert
9
9
9
5
5
5
5
5
5
5
5
5
5
4
4
4
4
Applikation
Immunofluorescence (IF), Western Blotting (WB)
112
64
47
28
25
21
4
3
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen Human MEK5
Klon LPR-01
Isotyp IgG1
Kreuzreaktivität Maus, Ratte (Rattus), Hund
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Reinigung Purified from tissue culture supernatant or ascites by affinity chromatography.
Andere Bezeichnung MEK5 (MAP2K5 Antibody Abstract)
Hintergrund The mitogen-activated protein (MAP) kinase cascade participates in the Ras signal transduction pathway. The MAP kinase cascade consists of MEK kinase (Raf-1 or B-Raf), MAP/ERK kinase (MEK1 or MEK2), and extracellular-regulated protein kinase (ERK1 or ERK2). Raf becomes activated following its interaction with Ras-GTP (activated Ras). Via phosphorylation reactions, Raf activates MEK which, in turn, activates ERK. MEK5, also known as MAP Kinase 5, is a 50 kDa protein that is 40% identical to MEK1 and MEK2. Alternative splicing results in two MEK5 isoforms: alpha (50 kDa) and beta (40 kDa). MEK5beta has been reported to be ubiquitously expressed while MEK5alpha is expressed primarily in the liver and brain. The N-terminal amino acid sequence of MEK5alpha resembles sequences found in actin cytoskeletal proteins, indicating that MEK5alpha may associate with the cytoskeleton. However, the role of MEK5 in the MAP kinase pathway and its substrate remain to be identified. This antibody is routinely tested by western blot analysis.
Synonyms: MAP Kinase-5
Molekulargewicht 50 kDa
Forschungsgebiet Cancer, Kinases/Phosphatases
Pathways MAPK Signalweg, Neurotrophin Signalübertragung
Kommentare

Related Products: ABIN968537, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Bilder des Herstellers
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (AA 13-188) antibody (ABIN968272) Western blot analysis of MEK5 on a Jurkat cell lysate (Human T-cell leukemia, ATCC TI...
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (AA 13-188) antibody (ABIN968272) Immunofluorescence staining on human endothelial cells.
Produkt verwendet in: English, Vanderbilt, Xu, Marcus, Cobb: "Isolation of MEK5 and differential expression of alternatively spliced forms." in: The Journal of biological chemistry, Vol. 270, Issue 48, pp. 28897-902, 1996 (PubMed).

Zhou, Bao, Dixon: "Components of a new human protein kinase signal transduction pathway." in: The Journal of biological chemistry, Vol. 270, Issue 21, pp. 12665-9, 1995 (PubMed).

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