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Aurora A Antikörper (AA 8-116)

AURKA Reaktivität: Human, Maus, Ratte WB, IF Wirt: Maus Monoclonal 4-IAK1 unconjugated
Produktnummer ABIN968261
  • Target Alle Aurora A (AURKA) Antikörper anzeigen
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Bindungsspezifität
    • 28
    • 22
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 8-116
    Reaktivität
    • 126
    • 73
    • 41
    • 20
    • 18
    • 14
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Maus, Ratte
    Wirt
    • 123
    • 20
    • 1
    Maus
    Klonalität
    • 110
    • 33
    Monoklonal
    Konjugat
    • 82
    • 10
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Aurora A Antikörper ist unkonjugiert
    Applikation
    • 105
    • 59
    • 37
    • 25
    • 19
    • 15
    • 12
    • 11
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Human, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse IAK1 aa. 8-116
    Klon
    4-IAK1
    Isotyp
    IgG1
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  • Kommentare

    Related Products: ABIN968537, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Kiat, Hui, Gopalan: "Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45558-65, (2002) (PubMed).

    Sakai, Urano, Ookata, Kim, Hirai, Saito, Nojima, Ishikawa: "MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48714-23, (2002) (PubMed).

    Katayama, Ota, Jisaki, Ueda, Tanaka, Odashima, Suzuki, Terada, Tatsuka: "Mitotic kinase expression and colorectal cancer progression." in: Journal of the National Cancer Institute, Vol. 91, Issue 13, pp. 1160-2, (1999) (PubMed).

    Gopalan, Chan, Donovan: "A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators." in: The Journal of cell biology, Vol. 138, Issue 3, pp. 643-56, (1997) (PubMed).

  • Target
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Andere Bezeichnung
    IAK1 (AURKA Produkte)
    Synonyme
    AIK antikoerper, ARK1 antikoerper, AURA antikoerper, AURORA2 antikoerper, BTAK antikoerper, PPP1R47 antikoerper, STK15 antikoerper, STK6 antikoerper, STK7 antikoerper, AIRK1 antikoerper, AU019385 antikoerper, AW539821 antikoerper, Ark1 antikoerper, Aurora-A antikoerper, Ayk1 antikoerper, IAK antikoerper, IAK1 antikoerper, Stk6 antikoerper, 87A7-9/2 antikoerper, Aur-A antikoerper, AurA antikoerper, CG3068 antikoerper, Dmel\\CG3068 antikoerper, aur-A antikoerper, aurA antikoerper, ck10 antikoerper, ck[10] antikoerper, l(3)87Ac antikoerper, l(3)ck10 antikoerper, ARK-1 antikoerper, Eg2 antikoerper, aik antikoerper, ark1 antikoerper, aur-a antikoerper, aura antikoerper, aurka-a antikoerper, aurora2 antikoerper, btak antikoerper, stk15 antikoerper, stk6 antikoerper, stk7 antikoerper, pEg2 antikoerper, wu:fb37c10 antikoerper, wu:fc02c02 antikoerper, zgc:100912 antikoerper, AURKA antikoerper, aurka antikoerper, aurora kinase A antikoerper, aurora A antikoerper, aurora kinase A L homeolog antikoerper, hypothetical protein antikoerper, aurora kinase A S homeolog antikoerper, AURKA antikoerper, Aurka antikoerper, aurA antikoerper, aurka.L antikoerper, aurka antikoerper, Aurora-A antikoerper, aurka.S antikoerper
    Hintergrund
    Cell division is a tightly regulated process that ensures the segregation of chromosomes into daughter cells. Essential to this regulation is the modification of cell cycle components by reversible phosphorylation. Ipl1 and aurora are two related kinases isolated from S.cerevisiae and Drosophila, respectively. Inactivation of these kinases results in abnormal chromosome segregation and disruption of the centrosome. A structurally and functionally similar kinase, IAK1 (Ipl1- and Aurora-related kinase 1), is a regulator of mammalian chromosome segregation. Although IAK1 may be present in the cytoplasm, it is detected on the centrosome following duplication and also associates with the spindle microtubules from metaphase through cell division. Expression of IAK1 is stringently regulated during the cell cycle. Both mRNA and protein are initially expressed in S-phase, are elevated during M-phase, and are undetectable following completion of mitosis. Increasing evidence suggests that IAK1 belongs to a novel subfamily of the ser/thr kinase superfamily. Although mutational analysis of IAK1 will directly determine its function, it appears to be a key player in the control of cell division.
    Synonyms: Aurora-A Kinase
    Molekulargewicht
    46 kDa
    Pathways
    Zellzyklus, Asymmetric Protein Localization
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