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Rab4 Antikörper (AA 97-213)

RAB4A Reaktivität: Human, Maus, Ratte, Hund WB, IF Wirt: Maus Monoclonal 7-Rab4 unconjugated
Produktnummer ABIN968232
  • Target Alle Rab4 (RAB4A) Antikörper anzeigen
    Rab4 (RAB4A) (RAB4A, Member RAS Oncogene Family (RAB4A))
    Bindungsspezifität
    • 16
    • 16
    • 7
    • 1
    • 1
    • 1
    AA 97-213
    Reaktivität
    • 68
    • 42
    • 24
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund
    Wirt
    • 58
    • 8
    • 2
    Maus
    Klonalität
    • 51
    • 17
    Monoklonal
    Konjugat
    • 29
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Rab4 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 20
    • 17
    • 16
    • 15
    • 14
    • 14
    • 13
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte (Rattus), Hund, Maus
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Rab4 aa. 97-213
    Klon
    7-Rab4
    Isotyp
    IgG1
    Top Product
    Discover our top product RAB4A Primärantikörper
  • Kommentare

    Related Products: ABIN968545, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Steiner, Sarria, Glauser, Magnin, Catsicas, Hirling: "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD." in: The Journal of cell biology, Vol. 157, Issue 7, pp. 1197-209, (2002) (PubMed).

    Sans, Racca, Petralia, Wang, McCallum, Wenthold: "Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 19, pp. 7506-16, (2001) (PubMed).

    Cormont, Bortoluzzi, Gautier, Mari, van Obberghen, Le Marchand-Brustel: "Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes." in: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6879-86, (1997) (PubMed).

    Zahraoui, Touchot, Chardin, Tavitian: "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion." in: The Journal of biological chemistry, Vol. 264, Issue 21, pp. 12394-401, (1989) (PubMed).

  • Target
    Rab4 (RAB4A) (RAB4A, Member RAS Oncogene Family (RAB4A))
    Andere Bezeichnung
    Rab4 (RAB4A Produkte)
    Synonyme
    rab4a antikoerper, MGC52945 antikoerper, fc93b03 antikoerper, wu:fc93b03 antikoerper, RAB4A antikoerper, HRES-1/RAB4 antikoerper, RAB4 antikoerper, AI848268 antikoerper, Rab4 antikoerper, RAB4A, member RAS oncogene family antikoerper, RAB4a, member RAS oncogene family antikoerper, rab4a antikoerper, RAB4A antikoerper, Rab4a antikoerper
    Hintergrund
    The Rab proteins are small GTP-binding molecules that are localized to specific intracellular vesicles and organelles and are important for vesicular trafficking. The Rab proteins cycle between active GTP-bound and inactive GDP-bound states. Rab4 is associated with early endosomes and recycling vesicles. It is involved in the recycling of receptors to the plasma membrane and regulates membrane recycling from early endosomes. Rab4 has been reported to be membrane-bound during interphase. However, it can be found as a cytosolic protein during mitosis. It is thought that Rab4 is phosphorylated by cdc2/cyclin B during mitosis and that Ser196 on Rab4 is the recognition site of cdc2. Mutation of Ser196 results in Rab4 membrane association during mitosis in an unphosphorylated form. Together this data indicates that Rab4 is phosphorylated by cdc2 on Ser196 which releases it into the cytosol during mitosis. In addition, Rab4 may play a role in insulin-induced glucose transport into rat adipocytes. Rab4 has also been reported to be associated with vesicles that contain GLUT4, a glucose transporter isoform. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    25 kDa
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