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Flotillin 1 Antikörper (AA 312-428)

FLOT1 Reaktivität: Human, Maus, Ratte, Huhn WB, IF Wirt: Maus Monoclonal 18-Flotillin unconjugated
Produktnummer ABIN968195
  • Target Alle Flotillin 1 (FLOT1) Antikörper anzeigen
    Flotillin 1 (FLOT1)
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 312-428
    Reaktivität
    • 59
    • 27
    • 26
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Huhn
    Wirt
    • 56
    • 2
    • 2
    Maus
    Klonalität
    • 48
    • 12
    Monoklonal
    Konjugat
    • 29
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Flotillin 1 Antikörper ist unkonjugiert
    Applikation
    • 38
    • 23
    • 10
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte (Rattus), Huhn, Human
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse Flotillin aa. 312-428
    Klon
    18-Flotillin
    Isotyp
    IgG1
    Top Product
    Discover our top product FLOT1 Primärantikörper
  • Kommentare

    Related Products: ABIN968545

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Cabin, Shimazu, Murphy, Cole, Gottschalk, McIlwain, Orrison, Chen, Ellis, Paylor, Lu, Nussbaum: "Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 20, pp. 8797-807, (2002) (PubMed).

    Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).

    Morrow, Rea, Martin, Prior, Prohaska, Hancock, James, Parton: "Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48834-41, (2002) (PubMed).

    Rybin, Xu, Lisanti, Steinberg: "Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41447-57, (2001) (PubMed).

    Bickel, Scherer, Schnitzer, Oh, Lisanti, Lodish: "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins." in: The Journal of biological chemistry, Vol. 272, Issue 21, pp. 13793-802, (1997) (PubMed).

  • Target
    Flotillin 1 (FLOT1)
    Andere Bezeichnung
    Flotillin-1 (FLOT1 Produkte)
    Synonyme
    reggie-2 antikoerper, flot1 antikoerper, Rareg antikoerper, flot1c antikoerper, flotillin-1 antikoerper, flotillin1 antikoerper, flot1a antikoerper, reggie2 antikoerper, si:dz44o19.1 antikoerper, wu:fj45g11 antikoerper, flotillin 1 antikoerper, flotillin-1 antikoerper, putative flotillin-1 antikoerper, flotillin 1 S homeolog antikoerper, flotillin 1 L homeolog antikoerper, flotillin 1a antikoerper, FLOT1 antikoerper, Flot1 antikoerper, flot1 antikoerper, LOC5566722 antikoerper, CpipJ_CPIJ008623 antikoerper, Smp_016200.1 antikoerper, flot1.S antikoerper, flot1.L antikoerper, flot1a antikoerper
    Hintergrund
    Caveolae are specialized membrane invaginations of 50-100 nm present in all cells, but abundant in endothelium, muscle cells, and adipocytes. These plasma membrane microdomains function in transcytosis of macromolecules, and are the sites of potocytosis, where small molecules are concentrated and transferred inside the cells by glycosylphosphatidylinositol (GPI)-linked receptors. Caveolin, a 22kDa protein and a well known marker for these plasma membrane microdomains, plays a structural role in these specializations. Flotillin-1 was isolated from the Triton X-100 insoluble buoyant fraction, characteristic of caveolae. Although the mRNA expression of both Flotillin-1 and Caveolin is very similar, Caveolin is undetectable in brain, while Flotillin-1 is very abundant. Flotillin-1 is a close homolog of the Epidermal Surface Antigen (ESA/Flotillin-2), which also colocalizes in the caveolae. Thus, Flotillin-1 and its relative ESA/Flotillin-2 are now incorporated into the expanding list of proteins co-localized at the caveolae which includes PKCalpha, Ras, Rap Src-like kinases, Galphaßgamma,and GPI-linked receptors. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    48 kDa
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