FKBP1A Antikörper (AA 1-108)

Produktnummer ABIN968189

Produktdetails anti-FKBP1A Antikörper

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Bindungsspezifität: AA 1-108

Reaktivität: Human, Maus, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FKBP1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Kreuzreaktivität: Maus, Hund, Huhn

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human FKBP12 aa. 1-108

Klon: 8-FKBP12

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968552, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-FKBP1A Antikörper (ABIN968189)

Chen, Liu, Massague: "Mechanism of TGFbeta receptor inhibition by FKBP12." in: The EMBO journal, Vol. 16, Issue 13, pp. 3866-76, (1997) (PubMed).

Wang, Donahoe, Zervos: "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12." in: Science (New York, N.Y.), Vol. 265, Issue 5172, pp. 674-6, (1994) (PubMed).

Details zu FKBP1A

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Andere Bezeichnung: FKBP12 (FKBP1A Produkte)

Synonyme: 12kDa antikoerper, FKBP12 antikoerper, FKBP12-T1 antikoerper, FKBP12-T2 antikoerper, Fkbp antikoerper, Fkbp1 antikoerper, mFKBP1 antikoerper, mFKBP12 antikoerper, FKBP-12 antikoerper, FKBP-1A antikoerper, FKBP1 antikoerper, Rotamase antikoerper, Fkbp12 antikoerper, ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12 antikoerper, ATFKBP12 antikoerper, FK506-binding protein 12 antikoerper, IMMUNOPHILIN antikoerper, MSJ1.19 antikoerper, MSJ1_19 antikoerper, PKC12 antikoerper, PKCI2 antikoerper, PPIASE antikoerper, FKBP1B antikoerper, Fkbp2 antikoerper, fj02g10 antikoerper, zgc:73373 antikoerper, wu:fj02g10 antikoerper, FKBP1A antikoerper, Bmfkbp13 antikoerper, zgc:103752 antikoerper, FK506 binding protein 1a antikoerper, FK506 binding protein 1A antikoerper, FK506-binding protein antikoerper, FK506-binding protein 12 antikoerper, FK506 binding protein 1Aa antikoerper, FK506 binding protein 1C antikoerper, FK506-binding protein 59 antikoerper, FK506 binding protein like antikoerper, FK506 binding protein 1A L homeolog antikoerper, FK506 binding protein 1Ab antikoerper, Fkbp1a antikoerper, FKBP1A antikoerper, Fkbp12 antikoerper, FKBP12 antikoerper, fkbp1aa antikoerper, FKBP1C antikoerper, EHI_180160 antikoerper, LOC5573443 antikoerper, Fkbp13 antikoerper, FKBPL antikoerper, fkbp1a.L antikoerper, fkbp1ab antikoerper

Hintergrund: Transforming growth factor-beta binds to the TGFbeta family of heteromeric serine/threonine transmembrane receptors (type I and type II). Following binding of TGFbeta, the type II receptor (TbetaR-II) phosphorylates the type I receptor (TbetaR-I) which, in turn, conveys the signal. Since TbetaR-I and TbetaR-II can interact without the stimulation of TGFbeta, leading to unwanted activation, a regulatory mechanism exists. In a yeast genetic screen, immunophilin FKBP12 was associated with the type I receptor. Studies including co-immunoprecipiation, deletion, and point mutations confirmed this interaction. FKBP12 inhibits TbetaR-II mediated phosphorylation of TbetaR-I, inhibiting activation. FKBP12 binds via its rapamycin/Leu-Pro binding pocket to the Leu-Pro sequence adjacent to the phosphorylation site of TbetaR-I. This interaction is blocked by the addition of macrolides, rapamycin, and FK506. Furthermore, mutations in the binding sites of FKBP12 and TbetaR-I abrogates the binding and results in activation of the receptor without the addition of TGFbeta. Thus, FKBP12 is a regulatory protein for TbetaR-I and TbetaR-II-mediated signaling.
Synonyms: FK506 Binding Protein 1A

Molekulargewicht: 14 kDa

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process