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CENPF Antikörper (AA 209-381)

CENPF Reaktivität: Human IHC, WB, IP, IF Wirt: Maus Monoclonal 11-Mitosin unconjugated
Produktnummer ABIN968167
  • Target Alle CENPF Antikörper anzeigen
    CENPF (Centromere Protein F (CENPF))
    Bindungsspezifität
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 209-381
    Reaktivität
    • 26
    • 2
    • 1
    • 1
    Human
    Wirt
    • 23
    • 3
    • 1
    Maus
    Klonalität
    • 24
    • 3
    Monoklonal
    Konjugat
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CENPF Antikörper ist unkonjugiert
    Applikation
    • 12
    • 9
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Mitosin aa. 209-381
    Klon
    11-Mitosin
    Isotyp
    IgG1
    Top Product
    Discover our top product CENPF Primärantikörper
  • Kommentare

    Related Products: ABIN968537, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Trinkle-Mulcahy, Andrews, Wickramasinghe, Sleeman, Prescott, Lam, Lyon, Swedlow, Lamond: "Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 107-17, (2003) (PubMed).

    Landberg, Erlanson, Roos, Tan, Casiano: "Nuclear autoantigen p330d/CENP-F: a marker for cell proliferation in human malignancies." in: Cytometry, Vol. 25, Issue 1, pp. 90-8, (1997) (PubMed).

    Casiano, Humbel, Peebles, Covini, Tan: "Autoimmunity to the cell cycle-dependent centromere protein p330d/CENP-F in disorders associated with cell proliferation." in: Journal of autoimmunity, Vol. 8, Issue 4, pp. 575-86, (1996) (PubMed).

    Zhu, Mancini, Chang, Liu, Chen, Shan, Jones, Yang-Feng, Lee: "Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression." in: Molecular and cellular biology, Vol. 15, Issue 9, pp. 5017-29, (1995) (PubMed).

    Rattner, Rao, Fritzler, Valencia, Yen: "CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization." in: Cell motility and the cytoskeleton, Vol. 26, Issue 3, pp. 214-26, (1994) (PubMed).

  • Target
    CENPF (Centromere Protein F (CENPF))
    Andere Bezeichnung
    Mitosin (CENPF Produkte)
    Synonyme
    LOC100222985 antikoerper, 6530404A22Rik antikoerper, AI325968 antikoerper, CENF antikoerper, Lek1 antikoerper, PRO1779 antikoerper, mitosin antikoerper, im:7140452 antikoerper, im:7144238 antikoerper, im:7154719 antikoerper, im:7156761 antikoerper, si:ch211-152h14.2 antikoerper, hcp-1 antikoerper, CMF1 antikoerper, centromere protein F antikoerper, CENPF antikoerper, Cenpf antikoerper, cenpf antikoerper
    Hintergrund
    Mitosin, a nuclear proetin of 3113 amino acids, contains a pair of tandem repeats and seven leucine repeats. In vitro, Mitosin directly interacts with the retinoblastoma protein, Rb. Mitosin is expressed throughout the cell cycle, with levels being lowest during G1, and it localizes at the kinetochore during the mitotic phase. The subcellular redistribution of Mitosin to the kinetochore is linked to its phosphorylation. Its expression is linked to patients with autoimmune diseases characterized by abnormal cell proliferation. Ectopic expression of a truncated version of Mitosin blocks the progression of the cell cycle. This suggests that the protein has an important role during cell proliferation. Because of similarities in subcellular localization and expression, Mitosin and the autoantigen p300/CENP-F, which is also linked to a multitude of autoimmune disorders, are probably the same protein.
    Molekulargewicht
    357 kDa
    Pathways
    Chromatin Binding, M Phase, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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