BCL2L1 Antikörper (AA 18-233)

Produktnummer ABIN968152

Produktdetails anti-BCL2L1 Antikörper

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Bindungsspezifität: AA 18-233

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCL2L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Maus, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Bcl-xl aa. 18-233

Klon: 44-Bcl

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968536, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-BCL2L1 Antikörper (ABIN968152)

Devarajan, De Leon, Talasazan, Schoenfeld, Davidowitz, Burk: "The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40599-605, (2001) (PubMed).

Oetzel, Jonuleit, Götz, van der Kuip, Michels, Duyster, Hallek, Aulitzky: "The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1958-68, (2000) (PubMed).

Soini, Kinnula, Kaarteenaho-Wiik, Kurttila, Linnainmaa, Pääkkö: "Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 5, Issue 11, pp. 3508-15, (2000) (PubMed).

Kishimoto, Sprent: "Strong TCR ligation without costimulation causes rapid onset of Fas-dependent apoptosis of naive murine CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 1817-26, (1999) (PubMed).

Anderson, Teutsch, Dong, Wortis: "An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10966-71, (1996) (PubMed).

Details zu BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Andere Bezeichnung: Bcl-x (BCL2L1 Produkte)

Synonyme: BCL-XL/S antikoerper, BCL2L antikoerper, BCLX antikoerper, BCLXL antikoerper, BCLXS antikoerper, Bcl-X antikoerper, PPP1R52 antikoerper, bcl-xL antikoerper, bcl-xS antikoerper, Bcl(X)L antikoerper, Bcl-XL antikoerper, Bcl-Xs antikoerper, Bcl2l antikoerper, BclX antikoerper, bcl-x antikoerper, Bcl-xl antikoerper, Bclx antikoerper, bcl-X antikoerper, Bcl-xL antikoerper, BCL-XL antikoerper, BCL2L1 antikoerper, bcl-XL antikoerper, bcl-x(l) antikoerper, bcl-xl/s antikoerper, bcl-xs antikoerper, bcl2l antikoerper, bclx antikoerper, bclxl antikoerper, xR11 antikoerper, bcl-xl antikoerper, blp1 antikoerper, cb1021 antikoerper, zfBLP1 antikoerper, BCL2 like 1 antikoerper, BCL2-like 1 antikoerper, Bcl2-like 1 antikoerper, BCL2-like 1 L homeolog antikoerper, bcl2-like 1 antikoerper, BCL2L1 antikoerper, Bcl2l1 antikoerper, bcl2l1 antikoerper, bcl2l1.L antikoerper

Hintergrund: Bcl-x is related to the Bcl-2 protein and can function independently of Bcl-2 in regulating apoptosis (programmed cell death). The bcl-x transcript is expressed in a number of tissues, with the highest levels in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xL and bcl-xS, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of the bcl-x gene. Bcl-xL is composed of 233 amino acids and is similar in size and structure to Bcl-2. The Bcl-xS polypeptide shows a deletion of 63 amino acids which consist of the region of Bcl-xL with the highest degree of amino acid identity to Bcl-2. Like Bcl-2, Bcl-xL inhibits cell death upon growth factor withdrawal when transfected into an IL-3-dependent cell line. However, Bcl-xS inhibits Bcl-2 mediated cell survival.

Molekulargewicht: 26 kDa

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling