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MCM2 Antikörper (AA 725-888)

MCM2 Reaktivität: Human, Maus, Ratte, Hund, Huhn WB, IHC, IF, IP Wirt: Maus Monoclonal 46-BM28 unconjugated
Produktnummer ABIN968121
  • Target Alle MCM2 Antikörper anzeigen
    MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))
    Bindungsspezifität
    • 19
    • 18
    • 16
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 725-888
    Reaktivität
    • 127
    • 72
    • 23
    • 10
    • 10
    • 9
    • 9
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Maus, Ratte, Hund, Huhn
    Wirt
    • 129
    • 13
    • 2
    • 1
    Maus
    Klonalität
    • 119
    • 26
    Monoklonal
    Konjugat
    • 80
    • 9
    • 9
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser MCM2 Antikörper ist unkonjugiert
    Applikation
    • 90
    • 53
    • 52
    • 28
    • 26
    • 26
    • 26
    • 25
    • 13
    • 11
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Huhn, Hund, Maus, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human BM28 aa. 725-888
    Klon
    46-BM28
    Isotyp
    IgG1
    Top Product
    Discover our top product MCM2 Primärantikörper
  • Kommentare

    Related Products: ABIN968536, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Cook, Park, Burke, Leone, DeGregori, Engel, Nevins: "Analysis of Cdc6 function in the assembly of mammalian prereplication complexes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 3, pp. 1347-52, (2002) (PubMed).

    Shreeram, Sparks, Lane, Blow: "Cell type-specific responses of human cells to inhibition of replication licensing." in: Oncogene, Vol. 21, Issue 43, pp. 6624-32, (2002) (PubMed).

    Todorov, Pepperkok, Philipova, Kearsey, Ansorge, Werner: "A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division." in: Journal of cell science, Vol. 107 ( Pt 1), pp. 253-65, (1994) (PubMed).

  • Target
    MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))
    Andere Bezeichnung
    BM28 (MCM2 Produkte)
    Synonyme
    CG7538 antikoerper, DmMCM2 antikoerper, DmMcm2 antikoerper, DmeMCM2 antikoerper, Dmel\\CG7538 antikoerper, MCM2 antikoerper, MCM2-7 antikoerper, MCM2_DROME antikoerper, McM2 antikoerper, PCR3 antikoerper, dMCM2 antikoerper, l(3)rL074 antikoerper, XMcm2 antikoerper, bm28 antikoerper, ccnl1 antikoerper, cdc19 antikoerper, cdcl1 antikoerper, mitotin antikoerper, cb737 antikoerper, chunp6905 antikoerper, BM28 antikoerper, CCNL1 antikoerper, CDCL1 antikoerper, D3S3194 antikoerper, MITOTIN antikoerper, MCM7 antikoerper, AA959861 antikoerper, AW476101 antikoerper, Mcmd2 antikoerper, mKIAA0030 antikoerper, Minichromosome maintenance 2 antikoerper, minichromosome maintenance complex component 2 antikoerper, minichromosome maintenance complex component 2 L homeolog antikoerper, Mcm2 antikoerper, mcm2 antikoerper, MCM2 antikoerper, mcm2.L antikoerper
    Hintergrund
    BM28 is a phosphoprotein that migrates at 125kDa in SDS PAGE with a hyperphosphorylated form migrating as a slightly slower band. The ratio of the phosphorylation states alters with the phases of cell cycle - in M, the fast phosphorylated BM28 is the major form found, while in G1 phase, the slow, hyperphosphorylated BM28 predominates. The cellular localization of BM28 is also cell cycle dependent. In G1, most of the BM28 is chromatin bound, whereas, by M phase, the BM28 is still nuclear, but not associated with the DNA. BM28 is necessary for both entry into S phase and cell division as determined by microinjection inhibition experiments. Microinjection of a BM28 antibody into synchronised cells in G1 phase inhibits DNA replication. When injected during S phase or later, no effect on DNA replication is seen, but cell division is inhibited.
    Molekulargewicht
    125 kDa
    Pathways
    DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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