SNRPN Antikörper (AA 14-174)

Produktnummer ABIN968085

Produktdetails anti-SNRPN Antikörper

Target: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Bindungsspezifität: AA 14-174

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SNRPN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Kreuzreaktivität: Maus, Ratte (Rattus), Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Alexa Fluor is a registered trademark of Molecular Probes, Inc., Eugene, OR.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human SMN aa. 14-174

Klon: 8-SMN

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968587, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-SNRPN Antikörper (ABIN968085)

Briese, Richter, Sattelle, Ulfig: "SMN, the product of the spinal muscular atrophy-determining gene, is expressed widely but selectively in the developing human forebrain." in: The Journal of comparative neurology, Vol. 497, Issue 5, pp. 808-16, (2006) (PubMed).

Côté, Boisvert, Boulanger, Bedford, Richard: "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 274-87, (2003) (PubMed).

Wang, Reddy, Shen: "Higher order arrangement of the eukaryotic nuclear bodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 21, pp. 13583-8, (2002) (PubMed).

Claus, Doring, Gringel, Muller-Ostermeyer, Fuhlrott, Kraft, Grothe: "Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 479-85, (2002) (PubMed).

Cifuentes-Diaz, Frugier, Tiziano, Lacène, Roblot, Joshi, Moreau, Melki: "Deletion of murine SMN exon 7 directed to skeletal muscle leads to severe muscular dystrophy." in: The Journal of cell biology, Vol. 152, Issue 5, pp. 1107-14, (2001) (PubMed).

Details zu SNRPN

Target: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Andere Bezeichnung: SMN (SNRPN Produkte)

Synonyme: SNRB' antikoerper, SNRPB' antikoerper, Snrpn antikoerper, zgc:77315 antikoerper, HCERN3 antikoerper, PWCR antikoerper, RT-LI antikoerper, SM-D antikoerper, SMN antikoerper, SNRNP-N antikoerper, SNURF-SNRPN antikoerper, sm-N antikoerper, 2410045I01Rik antikoerper, Peg4 antikoerper, Pwcr1 antikoerper, FE 294 antikoerper, FE 294 psi antikoerper, FE294 antikoerper, FE294 psi antikoerper, SNURF antikoerper, SNRPN antikoerper, QflA-11237 antikoerper, QtrA-10022 antikoerper, Sm-N antikoerper, SmN antikoerper, snRNP-N antikoerper, small nuclear ribonucleoprotein polypeptide-like antikoerper, small nuclear ribonucleoprotein polypeptides B and B1 antikoerper, small nuclear ribonucleoprotein polypeptide N antikoerper, small nuclear ribonucleoprotein N antikoerper, small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 antikoerper, SNRPN upstream reading frame antikoerper, Small nuclear ribonucleoprotein-associated protein N antikoerper, SNRPL antikoerper, snrpb antikoerper, SNRPN antikoerper, Snrpn antikoerper, snrpn antikoerper, SNURF antikoerper

Hintergrund: SMN (survival motor neuron) was discovered as a candidate gene, located in chromosome 5q13, for the fatal autosomal Spinal muscular atrophy (SMA) disorder. The SMN gene was missing or interrupted in a significant number of patients with SMA. The SMN protein is 294 amino acids and migrates with apparent molecular weight of 40 kDa. In addition to the cytoplasm, other studies localized SMN in dots of 0.1-1.0 µm within the nucleus. These novel nuclear structures were named gems and found associated to coiled bodies. It was also found that SMN interacts with the RGG box of hnRNP U and fibrillarin. Therefore, the biochemical function of SMN may be in the regulation of mRNA metabolism.
Synonyms: Survival Motor Neuron

Molekulargewicht: 40 kDa