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Gephyrin Antikörper (AA 569-726)

GPHN Reaktivität: Human, Maus, Ratte, Huhn WB, IHC, IF, IP Wirt: Maus Monoclonal 45-Gephyrin unconjugated
Produktnummer ABIN968050
  • Target Alle Gephyrin (GPHN) Antikörper anzeigen
    Gephyrin (GPHN)
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 569-726
    Reaktivität
    • 54
    • 36
    • 27
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Maus, Ratte, Huhn
    Wirt
    • 48
    • 7
    • 1
    • 1
    Maus
    Klonalität
    • 43
    • 14
    Monoklonal
    Konjugat
    • 30
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Gephyrin Antikörper ist unkonjugiert
    Applikation
    • 38
    • 19
    • 19
    • 16
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Huhn, Human, Maus
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat Gephyrin aa. 569-726
    Klon
    45-Gephyrin
    Isotyp
    IgG1
    Top Product
    Discover our top product GPHN Primärantikörper
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    Related Products: ABIN968546, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Feng, Tintrup, Kirsch, Nichol, Kuhse, Betz, Sanes: "Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity." in: Science (New York, N.Y.), Vol. 282, Issue 5392, pp. 1321-4, (1998) (PubMed).

    Meyer, Kirsch, Betz, Langosch: "Identification of a gephyrin binding motif on the glycine receptor beta subunit." in: Neuron, Vol. 15, Issue 3, pp. 563-72, (1995) (PubMed).

    Prior, Schmitt, Grenningloh, Pribilla, Multhaup, Beyreuther, Maulet, Werner, Langosch, Kirsch: "Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein." in: Neuron, Vol. 8, Issue 6, pp. 1161-70, (1992) (PubMed).

  • Target
    Gephyrin (GPHN)
    Andere Bezeichnung
    Gephyrin (GPHN Produkte)
    Synonyme
    5730552E08Rik antikoerper, AI662856 antikoerper, BC027112 antikoerper, C230040D23 antikoerper, GPH antikoerper, GPHRYN antikoerper, geph antikoerper, Geph antikoerper, GPHN antikoerper, GEPH antikoerper, HKPX1 antikoerper, gpgb1 antikoerper, DKFZp459M0825 antikoerper, gephyrin antikoerper, gephyrin L homeolog antikoerper, gephyrin a antikoerper, Gphn antikoerper, GPHN antikoerper, gphn.L antikoerper, gphna antikoerper, PTRG_08978 antikoerper, VDBG_00775 antikoerper, Tsp_03043 antikoerper, gphn antikoerper
    Hintergrund
    The sub-membraneous region of the postsynaptic neuron is an intricate network of cytoskeletal elements generally known as the postsynaptic density. It is thought that this elaborate cytoskeletal region is critical for receptor targeting, clustering, and efficient signal input. Gephyrin, a 93 kDa protein, was identified as a result of its ability to bind to polymerized tubulin (microtubules). Although expressed in all tissues, gephyrin mRNA is found most abundantly in brain. Alternative splicing produces at least five different mRNAs. Gephyrin colocalizes and interacts with the glycine receptor at the postsynaptic density. It is possible that Gephyrin acts as an anchor between the glycine receptor and microtubules. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    93 kDa
    Pathways
    Synaptic Membrane, Skeletal Muscle Fiber Development
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