DAB2 Antikörper (AA 31-45)

Produktnummer ABIN967990

Produktdetails anti-DAB2 Antikörper

Target: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Bindungsspezifität: AA 31-45

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DAB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse p96 aa. 31-45

Klon: 52-p96

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-DAB2 Antikörper (ABIN967990)

Mishra, Keyel, Hawryluk, Agostinelli, Watkins, Traub: "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor." in: The EMBO journal, Vol. 21, Issue 18, pp. 4915-26, (2002) (PubMed).

Hocevar, Smine, Xu, Howe: "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway." in: The EMBO journal, Vol. 20, Issue 11, pp. 2789-801, (2001) (PubMed).

Smith, Capo-chichi, He, Smedberg, Yang, Prowse, Godwin, Hamilton, Xu: "Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells." in: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 47303-10, (2001) (PubMed).

Xu, Yang, Jackowski, Rock: "Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14184-91, (1995) (PubMed).

Details zu DAB2

Target: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Andere Bezeichnung: p96 (DAB2 Produkte)

Synonyme: DOC-2 antikoerper, DOC2 antikoerper, 5730435J12Rik antikoerper, AA960054 antikoerper, AI957090 antikoerper, D15Wsu122e antikoerper, D630005B22Rik antikoerper, Doc-2 antikoerper, Doc2 antikoerper, p96 antikoerper, DAB2, clathrin adaptor protein antikoerper, disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) antikoerper, Dab, mitogen-responsive phosphoprotein, homolog 2 antikoerper, disabled 2, mitogen-responsive phosphoprotein antikoerper, DAB2 antikoerper, dab2 antikoerper, Dab2 antikoerper

Hintergrund: CSF-1 is a growth factor that stimulates the growth and differentiation of immature lymphocytes and is required for the survival of mononuclear phagocytes. Binding of CSF-1 induces dimerization and autophosphorylation of its receptor. This results in the activation of several signal transduction pathways. A unique 96 kDa protein is a component in the CSF-1 signal transduction cascade. p96 is phosphorylated on serine following mitogenic stimulation of a mouse macrophage cell line. p96 contains three potential C-terminal ERK kinase phosphorylation sites, as well as several proline-rich sequences that are potential binding sites for SH3-containing proteins. Structural similarities have been found between p96 and Dab, a product of the Drosophila disabled gene, and p96 was also identified as Disabled-2 (Dab-2) and as differentially expressed in ovarian carcinoma-2 (DOC-2) . Dab-2/p96 has been shown to be essential for TGFbeta signaling by facilitating signal transduction from the TGFbeta receptor to the Smad family of transcription factors. Thus, Dab-2/p96 is an important adaptor molecule in growth factor signaling pathways.
Synonyms: Disabled-2

Molekulargewicht: 96 kDa

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process