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BDKRB2 Antikörper (AA 350-364)

BDKRB2 Reaktivität: Human, Ratte WB, IHC, IF, IP Wirt: Maus Monoclonal 20-B2 Bradykinin Receptor unconjugated
Produktnummer ABIN967979
  • Target Alle BDKRB2 Antikörper anzeigen
    BDKRB2 (Bradykinin Receptor B2 (BDKRB2))
    Bindungsspezifität
    • 16
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 350-364
    Reaktivität
    • 36
    • 36
    • 22
    • 2
    • 1
    Human, Ratte
    Wirt
    • 49
    • 4
    Maus
    Klonalität
    • 41
    • 12
    Monoklonal
    Konjugat
    • 17
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BDKRB2 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 19
    • 13
    • 13
    • 10
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    5. For fluorochrome spectra and suitable instrument settings, please refer to us.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human B2 Bradykinin Receptor aa. 350-364
    Klon
    20-B2 Bradykinin Receptor
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product BDKRB2 Primärantikörper
  • Kommentare

    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Ewert, Johansson, Holm, Helander, Fandriks: "The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion." in: BMC physiology, Vol. 3, pp. 1, (2003) (PubMed).

    Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, (2002) (PubMed).

    Xie, Browning, Hay, Mackman, Ye: "Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt." in: The Journal of biological chemistry, Vol. 275, Issue 32, pp. 24907-14, (2000) (PubMed).

    Golser, Gorren, Leber, Andrew, Habisch, Werner, Schmidt, Venema, Mayer: "Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5291-6, (2000) (PubMed).

    Powell, Slynn, Thomas, Hopkins, Briggs, Graham: "Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14." in: Genomics, Vol. 15, Issue 2, pp. 435-8, (1993) (PubMed).

  • Target
    BDKRB2 (Bradykinin Receptor B2 (BDKRB2))
    Andere Bezeichnung
    B2 Bradykinin Receptor (BDKRB2 Produkte)
    Synonyme
    BDKRB2 antikoerper, b2r antikoerper, bk2 antikoerper, bk-2 antikoerper, bkr2 antikoerper, brb2 antikoerper, kinrec antikoerper, B2R antikoerper, BK-2 antikoerper, BK2 antikoerper, BKR2 antikoerper, BRB2 antikoerper, B2BKR antikoerper, B2BRA antikoerper, B(2) antikoerper, B2 antikoerper, BK2R antikoerper, Bdkrb2 antikoerper, bradykinin receptor B2 antikoerper, bradykinin receptor, beta 2 antikoerper, bradykinin type 2 receptor antikoerper, Bdkrb2 antikoerper, BDKRB2 antikoerper, bdkrb2 antikoerper, kinrec antikoerper, B2R antikoerper
    Hintergrund
    Bradykinin is a nine amino acid vasoactive peptide that elicits numerous physiologic responses such as vasodilation, smooth muscle spasm, and pain. Bradykinin is one of a family of such peptides called the kinins. The kinins are generated from high molecular weight precursors called kininogens from proteolysis induced by pathophysiologic conditions such as inflammation or allergy. The physiological actions of these kinins are mediated by their interaction with transmembrane receptors. There are two distinct bradykinin receptor subtypes: B1 and B2. Both are coupled to G-proteins. The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas, the B1 receptors are only detected following tissue injury. The B2 receptor is similar in structure to other seven helix G-protein coupled receptors. Bradykinin has a relatively low affinity for B1 receptors, and interacts primarily with the B2 receptor. This interaction stimulates several second messenger systems, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and hyperpolarization.
    Molekulargewicht
    42 kDa
    Pathways
    ACE Inhibitor Pathway, Negative Regulation of intrinsic apoptotic Signaling
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