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NOS2 Antikörper (AA 961-1144)

NOS2 Reaktivität: Maus WB, IHC, IP, IF Wirt: Maus Monoclonal 6-iNOS-NOS Type II unconjugated
Produktnummer ABIN967905
  • Target Alle NOS2 Antikörper anzeigen
    NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))
    Bindungsspezifität
    • 16
    • 16
    • 12
    • 10
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 961-1144
    Reaktivität
    • 110
    • 73
    • 69
    • 17
    • 2
    • 1
    Maus
    Wirt
    • 127
    • 14
    Maus
    Klonalität
    • 119
    • 22
    Monoklonal
    Konjugat
    • 73
    • 16
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser NOS2 Antikörper ist unkonjugiert
    Applikation
    • 114
    • 45
    • 38
    • 32
    • 27
    • 27
    • 26
    • 18
    • 18
    • 17
    • 8
    • 4
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse iNOS aa. 961-1144
    Klon
    6-iNOS-NOS Type II
    Isotyp
    IgG2a
    Top Product
    Discover our top product NOS2 Primärantikörper
  • Kommentare

    Related Products: ABIN968550, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Heneka, Klockgether, Feinstein: "Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 18, pp. 6862-7, (2000) (PubMed).

    Marrogi, Pass, Khan, Metheny-Barlow, Harris, Gerwin: "Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor." in: Cancer research, Vol. 60, Issue 14, pp. 3696-700, (2000) (PubMed).

    Miles, Bowman, Rao, Baatz, Huffman: "Pulmonary surfactant inhibits LPS-induced nitric oxide production by alveolar macrophages." in: The American journal of physiology, Vol. 276, Issue 1 Pt 1, pp. L186-96, (1999) (PubMed).

    Sciorati, Rovere, Ferrarini, Heltai, Manfredi, Clementi: "Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes." in: The Journal of biological chemistry, Vol. 272, Issue 37, pp. 23211-5, (1997) (PubMed).

    Xie, Cho, Calaycay, Mumford, Swiderek, Lee, Ding, Troso, Nathan: "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages." in: Science (New York, N.Y.), Vol. 256, Issue 5054, pp. 225-8, (1992) (PubMed).

  • Target
    NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))
    Andere Bezeichnung
    iNOS/NOS Type II (NOS2 Produkte)
    Synonyme
    HEP-NOS antikoerper, INOS antikoerper, NOS antikoerper, NOS2A antikoerper, NOS-II antikoerper, Nos-2 antikoerper, Nos2a antikoerper, i-NOS antikoerper, iNOS antikoerper, iNos antikoerper, NOS2a antikoerper, NOS2 antikoerper, BmNOS2 antikoerper, Nsl antikoerper, nos2 antikoerper, nitric oxide synthase 2 antikoerper, nitric oxide synthase 2, inducible antikoerper, inducible nitric oxide synthase antikoerper, inducible nitric-oxide synthase antikoerper, nanos C2HC-type zinc finger 2 antikoerper, NOS2 antikoerper, Nos2 antikoerper, nos2 antikoerper, LOC396821 antikoerper, NANOS2 antikoerper
    Hintergrund
    Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In macrophages and other cell types, NOS (iNOS or macNOS) activity increases following exposure to cytokines (IFN-gamma, TNF-alpha, and IL-1) and microbial products (lipopolysaccharide (LPS)), iNOS is activated independently of Ca2+/calmodulin and its level of expression is tightly controlled by several transcription factors, including NFkappaB. Data indicates that TGF-beta affects translation of iNOS mRNA and decreases iNOS protein stability. Normally undetectable in brain tissue, iNOS mRNA has been observed in CNS tissues of animals under experimental pathologic conditions. iNOS and nNOS share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain.
    Molekulargewicht
    130 kDa
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Inositol Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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